Effects of Physical Activity on the Brain in Impaired Glucose Tolerance (IGT)
Phase 4
Completed
- Conditions
- Impaired Glucose Tolerance
- Interventions
- Behavioral: Exercise
- Registration Number
- NCT01219231
- Lead Sponsor
- Charite University, Berlin, Germany
- Brief Summary
The researchers will investigate whether exercise could provide positive effects on general brain functions in elderly people with impaired glucose tolerance.
- Detailed Description
The age-related degradation of cognitive functions even to the point of neurodegenerative disorders such as Alzheimer's disease are a growing public-health concern with devastating effects.
Referring to animal data, empirical studies, and pilot human trials, exercise should improve cognitive functions such as learning and memory. To test this hypothesis, the researchers study general brain functions in elderly subjects (50-80 years old) with impaired glucose tolerance during a short term exercise program.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 46
Inclusion Criteria
- subjects with impaired glucose tolerance
- 50-65 years old
- moderate to heavy weight (BMI 25-35)
- must be able to do exercise intervention
Exclusion Criteria
- diabetes
- younger than 50 years
- BMI < 25
- psychiatric medication
- severe disease
- MMSE < 26
- severe cardiovascular disorders
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Exercise Exercise - Placebo Exercise -
- Primary Outcome Measures
Name Time Method Auditory Verbal Learning Task Prior to intervention and after 6 months of intervention
- Secondary Outcome Measures
Name Time Method Plasma biomarkers Prior to intervention and after 6 months of intervention Functional/Structural brain changes Prior to intervention and after 6 months of intervention
Trial Locations
- Locations (1)
Department of Neurology, Charité Universitätsmedizin
🇩🇪Berlin, Germany