Exercise in Elderly Individuals With Impaired Glucose Tolerance: Beneficial for Vasculature and Neurons?
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Impaired Glucose Tolerance
- Sponsor
- Charite University, Berlin, Germany
- Enrollment
- 46
- Locations
- 1
- Primary Endpoint
- Auditory Verbal Learning Task
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The researchers will investigate whether exercise could provide positive effects on general brain functions in elderly people with impaired glucose tolerance.
Detailed Description
The age-related degradation of cognitive functions even to the point of neurodegenerative disorders such as Alzheimer's disease are a growing public-health concern with devastating effects. Referring to animal data, empirical studies, and pilot human trials, exercise should improve cognitive functions such as learning and memory. To test this hypothesis, the researchers study general brain functions in elderly subjects (50-80 years old) with impaired glucose tolerance during a short term exercise program.
Investigators
Agnes Flöel
Prof
Charite University, Berlin, Germany
Eligibility Criteria
Inclusion Criteria
- •subjects with impaired glucose tolerance
- •50-65 years old
- •moderate to heavy weight (BMI 25-35)
- •must be able to do exercise intervention
Exclusion Criteria
- •younger than 50 years
- •BMI \< 25
- •psychiatric medication
- •severe disease
- •MMSE \< 26
- •severe cardiovascular disorders
Outcomes
Primary Outcomes
Auditory Verbal Learning Task
Time Frame: Prior to intervention and after 6 months of intervention
Secondary Outcomes
- Functional/Structural brain changes(Prior to intervention and after 6 months of intervention)
- Plasma biomarkers(Prior to intervention and after 6 months of intervention)