Physical Activity and Cognitive Function in Older Adults: A Novel Role for GPLD1
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Aging
- Sponsor
- Pennington Biomedical Research Center
- Enrollment
- 25
- Locations
- 1
- Primary Endpoint
- Plasma concentrations of GPLD1
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The investigators are conducting a cross-sectional, observational study to investigate whether plasma GPLD1 concentrations are associated with higher cognitive function and better brain structure and function in two groups of older adults with high or low levels of physical activity.
Detailed Description
This is a cross-sectional, observational study which will enroll up to 28 healthy, older adults (65-85 y, BMI 20-35 kg/m2), and stratify by current self-reported physical activity level (equal inactive vs. equal highly active). Aim 1: Investigate whether physical activity level is associated with GPLD1. Aim 2: Investigate whether cognitive function and brain structure/function are associated with GPLD1.
Investigators
Eric Ravussin
Associate Executive Director for Clinical Science
Pennington Biomedical Research Center
Eligibility Criteria
Inclusion Criteria
- •Ages 65-85 y (inclusive)
- •Body mass index (BMI) of 20-35 kg/m2 (inclusive)
- •Willing to have blood and data stored for future research use
Exclusion Criteria
- •History of clinically diagnosed diabetes (Type 1 or 2) or a fasting blood glucose \>126 mg/dL
- •Diagnosed Alzheimer's disease, dementia, or related-brain diseases
- •Chronic use of atypical antipsychotic or bipolar medications
- •Initiation of novel pharmacotherapy agents (such as antidepressant, hypertension, or dyslipidemia) within the last 3 months
- •Uncontrolled hypertension (blood pressure \>160 systolic or \>110 diastolic)
- •Asthma that limits the ability to participate in moderate to vigorous physical activity or requiring systemic glucocorticoid administration
- •Emphysema that limits the ability to participate in moderate to vigorous physical activity or requiring systemic glucocorticoid administration
- •Current alcohol use exceeding 14 drinks per week in women, exceeding 21 drinks per week in men, having treatment for alcohol abuse in the last year, or having treatment for alcohol abuse more than 1 year ago (but with inability to refrain from alcohol in the past year)
- •Use of illegal drugs or marijuana within 1-month of completing a Screening Visit; treatment for drug addiction in the 1-year or having treatment for drug addiction \>1-year ago, but with an inability to refrain from the drug of addiction in the 1-year
- •Unwilling to abstain from illegal drugs and marijuana for the duration of the study
Outcomes
Primary Outcomes
Plasma concentrations of GPLD1
Time Frame: 1 day
Plasma GPLD1 (by a blood draw) is performed.
Secondary Outcomes
- Physical activity level(7 days)
- Brain activity and function(1 day)
- Total grey matter volume(1 day)
- Cognitive function(1 day)