Neural Activation and Connectivity in Response to Exercise and Cognitive Training
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Neural Connectivity
- Sponsor
- Washington University School of Medicine
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- Functional connectivity of large-scale brain networks as seen through Blood Oxygen Level Dependent (BOLD) functional magnetic resonance imaging (fMRI)
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
The goal of this pilot study is to evaluate whether healthy, sedentary older adults have increased activation of specific brain areas, in response to exercise and cognitive training, in comparison to a control group, and whether improvements in psychometric test performance are related to increased activation of brain networks. Participants, between age 55-75 years will be recruited from an ongoing study of exercise and cognitive training, to undergo Blood Oxygen Level Dependent (BOLD) functional magnetic imaging (fcMRI).
Investigators
Eligibility Criteria
Inclusion Criteria
- •meet the inclusion criteria for the parent study, Combining Exercise and Cognitive Training to Improve Everyday Function (EXACT) study (Unique Protocol ID 201102416).
Exclusion Criteria
- •currently taking chronic psychotropic medication, beta blockers, or calcium channel blockers
- •contraindication to MRI scanning
- •inability to complete MRI scans in closed scanner
Outcomes
Primary Outcomes
Functional connectivity of large-scale brain networks as seen through Blood Oxygen Level Dependent (BOLD) functional magnetic resonance imaging (fMRI)
Time Frame: Change in connectivity measurements between baseline and 6 months