Randomized, Controlled Study About the Effects of an Exercise Program and Mental Activity on the Age-Associated Impairment of Cognitive Function
试验速览
- 阶段
- 3 期
- 入组人数
- 252
- 试验地点
- 4
- 主要终点
- Improvement of cognitive and physical performance
研究概览
简要总结
The trial will evaluate the effects of frequent exercise and increased mental activity on the age-related impairment of cognitive function in elderly women. Furthermore, we will assess the effects of exercise and mental activity on the mood, physical performance and mental status of participants. We will also search for genetic factors which may be responsible of the observed outcomes.
详细描述
Two-hundred and fifty-two women older than 70 years will be randomize to one of three groups. The first (exercise) will participate at an exercise program three times weekly for 90 minutes. The training will consist of an endurance and resistance training and will be carried out in a group. Participants in the second group (mental training) will take computer lessons, three times weekly for 90 minutes. Both interventions will be carried out for 26 weeks. Participants in the third group (control) will not participate at an structured intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 70 Years 至 —（Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •All healthy women older than 70 years with sufficient knowledge of German can participate.
排除标准
- •Chronic mental disorders
- •Chronic neurological, cardiological, pulmonary or renal diseases.
- •Severe osteoarthritis
- •Disorders which can be aggravated by exercise (arterial hypertension, coronary heart disease, COLD).
- •Cancer in current therapy
- •Treatment with glucocorticoids or cytostatic drugs.
- •Patients who received an organ transplantation
- •Exercise-induced osteoarticular pain
结局指标
主要结局
Improvement of cognitive and physical performance
时间窗: 6 months
次要结局
未报告次要终点