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临床试验/NCT00522899
NCT00522899
已完成
不适用

The Effects of Mental Activity and Exercise on Cognitive Function in Older Adults Who Self-Report a Recent Decline in Memory or Thinking

University of California, San Francisco2 个研究点 分布在 1 个国家目标入组 126 人2007年8月

概览

阶段
不适用
干预措施
未指定
疾病 / 适应症
Cognitive Impairment
发起方
University of California, San Francisco
入组人数
126
试验地点
2
主要终点
Change in cognitive function summary score
状态
已完成
最后更新
14年前

概览

简要总结

The primary objective of this study is to conduct a randomized, controlled trial to determine whether engaging in mental activity or exercise, either alone or in combination, improves cognitive function in non-demented, inactive older adults who self-report a recent decline in memory or thinking. In addition, we, the researchers at the University of California, San Francisco, plan to seek funding to follow subjects over time to determine whether these interventions are associated with changes in rate of cognitive decline or risk of dementia after the intervention period has ended.

详细描述

SPECIFIC AIMS AND HYPOTHESES Aim 1: To determine whether a 12-week, computer-based mental activity program improves cognitive function in non-demented, inactive elders. We hypothesize that this mental activity program will improve cognitive function-especially visuospatial function-in non-demented, inactive elders. Aim 2: To determine whether a 12-week exercise program improves cognitive function in non-demented, inactive elders. We hypothesize that this exercise program will improve cognitive function-especially executive function-in non-demented, inactive elders. Aim 3: To determine whether the effects of mental activity and exercise are additive or are more or less than the sum of their parts. We hypothesize that the effects of these mental activity and exercise interventions will be additive. Aim 4: To determine whether mental activity and/or exercise may slow cognitive decline or lower risk of dementia in non-demented, inactive elders. We hypothesize that both mental activity and exercise will slow cognitive decline and lower risk of dementia, and that the effects will be greatest when mental activity and exercise are combined.

注册库
clinicaltrials.gov
开始日期
2007年8月
结束日期
2011年6月
最后更新
14年前
研究类型
Interventional
研究设计
Factorial
性别
All

研究者

责任方
Principal Investigator
主要研究者

Deborah Barnes

Associate Professor, Psychiatry and Epidemiology & Biostatistics

University of California, San Francisco

入排标准

入选标准

  • Age \> 64
  • Self-report of recent decline in memory or thinking
  • Low/no physical activity (\<2 days/week for \<30 minutes/session of moderate intensity activity over past 3 months)
  • Low/no computer mental activity (\<2 days/week for \<30 minutes/session over past 3 months)
  • Fluent in English
  • Willingness to perform study activities

排除标准

  • Evidence of dementia (based on self-report, physician diagnosis or score \< 19 on Telephone Interview for Cognitive Status)
  • Significant central nervous system disorder (Parkinson's disease, multiple sclerosis, ALS \[Lou Gerig's disease\])
  • Major, current psychiatric disorder (major depressive disorder, schizophrenia, bipolar disorder, post-traumatic stress disorder, obsessive-compulsive disorder, psychiatric hospitalization in past 20 years)
  • Major central nervous system event (stroke, transient ischemic attack/mini-stroke, seizure, or traumatic brain injury that has left a residual deficit)
  • Significant heart disease (severe congestive heart failure, severe aortic stenosis, cardiac arrest, uncontrolled angina)
  • Significant lung disease (requiring supplemental oxygen or oral or injected steroids)
  • Other condition that would make participation potentially dangerous (cancer requiring treatment in past 3 years, severe arthritis, history of cardiac defibrillation, dialysis)
  • Lack of physician approval
  • Severe hearing or visual impairment
  • History of learning disability

结局指标

主要结局

Change in cognitive function summary score

时间窗: 12 weeks

次要结局

  • Visual processing speed summary score (mental activity group), executive function summary score (exercise group), other measures (e.g., leisure activity, physical performance, physical function, depressive symptoms, sleep quality)(12 weeks)

研究点 (2)

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