Effects of Physical Activity on the Brain in Parkinson's Disease (PD)

Charite University, Berlin, Germany1 site in 1 country20 target enrollmentDecember 2010

ConditionsParkinson's Disease

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Parkinson's Disease
Sponsor: Charite University, Berlin, Germany
Enrollment: 20
Locations: 1
Primary Endpoint: UPDRS motor score
Status: Completed
Last Updated: 10 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The aim of the study is to investigate whether exercise improves cognitive and motor functions in Parkinson's disease. To test this hypothesis, the researchers study general brain functions in subjects with PD during a 6-months exercise program.

Registry

clinicaltrials.gov

Start Date

December 2010

End Date

September 2014

Last Updated

10 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Charite University, Berlin, Germany

Responsible Party

Principal Investigator

Agnes Flöel

Prof. Dr. med. Agnes Floeel

Charite University, Berlin, Germany

Eligibility Criteria

Inclusion Criteria

•UPDRS \<15
•L-DOPA responsive
•\<5 yrs since diagnosis

Exclusion Criteria

•severe other diseases
•MMSE \< 26
•treatment with psychiatric medication

Outcomes

Primary Outcomes

UPDRS motor score

Time Frame: Prior to intervention and after 6 months of intervention

Secondary Outcomes

Cognitive Function based on neuropsychological test-performance(Prior to intervention and after 6 months of intervention)
Plasma biomarkers(Prior to intervention and after 6 months of intervention)
Functional/Structural brain changes(Prior to intervention and after 6 months of intervention)