Effects of Physical Activity on the Brain in Parkinson's Disease (PD)

Not Applicable

Completed

• Conditions: Parkinson's Disease
• Interventions: Behavioral: aerobic; Behavioral: stationary bike exercise

• Registration Number: NCT01741584
• Lead Sponsor: Charite University, Berlin, Germany

Brief Summary

The aim of the study is to investigate whether exercise improves cognitive and motor functions in Parkinson's disease. To test this hypothesis, the researchers study general brain functions in subjects with PD during a 6-months exercise program.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-12
• Study First Submitted: 2012-12-03
• Study First Submitted QC: 2012-12-03
• Study First Posted: 2012-12-05
• Primary Completion: 2014-09
• Status Verified: 2016-03
• Last Update Submitted: 2016-03-15
• Last Update Posted: 2016-03-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• UPDRS <15
• L-DOPA responsive
• <5 yrs since diagnosis

Exclusion Criteria

• severe other diseases
• MMSE < 26
• treatment with psychiatric medication

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
aerobic	aerobic	6 months of exercise \<30% anaerobic threshold
stationary bike exercise	stationary bike exercise	6 months of exercise (60% of anaerobic threshold)

Primary Outcome Measures

Name	Time	Method
UPDRS motor score	Prior to intervention and after 6 months of intervention

Secondary Outcome Measures

Name	Time	Method
Cognitive Function based on neuropsychological test-performance	Prior to intervention and after 6 months of intervention
Plasma biomarkers	Prior to intervention and after 6 months of intervention
Functional/Structural brain changes	Prior to intervention and after 6 months of intervention

Trial Locations

Locations (1)

Department of Neurology, Charité Universitätsmedizin Berlin; 🇩🇪 Berlin, Germany