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Clinical Trials/NCT01741584
NCT01741584CompletedNot Applicable

Effects of Physical Activity on the Brain in Parkinson's Disease (PD)

Charite University, Berlin, Germany2 sites in 1 country20 target enrollmentStarted: December 2010Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
20
Locations
2
Primary Endpoint
UPDRS motor score
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

The aim of the study is to investigate whether exercise improves cognitive and motor functions in Parkinson's disease. To test this hypothesis, the researchers study general brain functions in subjects with PD during a 6-months exercise program.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Prevention
Masking
Triple (Participant, Investigator, Outcomes Assessor)

Eligibility Criteria

Ages
35 Years to 80 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •UPDRS <15
  • •L-DOPA responsive
  • •<5 yrs since diagnosis

Exclusion Criteria

  • •severe other diseases
  • •MMSE < 26
  • •treatment with psychiatric medication

Outcomes

Primary Outcomes

UPDRS motor score

Time Frame: Prior to intervention and after 6 months of intervention

Secondary Outcomes

  • Cognitive Function based on neuropsychological test-performance(Prior to intervention and after 6 months of intervention)
  • Plasma biomarkers(Prior to intervention and after 6 months of intervention)
  • Functional/Structural brain changes(Prior to intervention and after 6 months of intervention)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Agnes Flöel

Prof. Dr. med. Agnes Floeel

Charite University, Berlin, Germany

Study Sites (2)

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Effects of Physical Activity on the Brain... | Clinical Trial