Effect of Aldosterone Blockade on Arterial Compliance

Phase 4

Completed

• Conditions: Arterial Stiffness; Arterial Elasticity
• Interventions: Drug: Spironolactone

• Registration Number: NCT01089309
• Lead Sponsor: Wolfson Medical Center

Brief Summary

The present study investigated the long-term (12 months) effect of spironolactone treatment on glucose homeostasis, metabolic parameters and vascular properties.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-05
• Primary Completion: 2007-06
• Study Completion: 2007-06
• Status Verified: 2010-03
• Study First Submitted: 2010-03-07
• Study First Submitted QC: 2010-03-17
• Study First Posted: 2010-03-18
• Last Update Submitted: 2010-03-26
• Last Update Posted: 2010-03-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 51

Inclusion Criteria

1. patients with type 2 diabetes mellitus

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Exclusion Criteria

1. history of unstable angina, myocardial infarction (MI), cerebrovascular accident (CVA)
2. major surgery within the six months preceding entrance to the study
3. unbalanced endocrine disease
4. any disease that might affect absorption of medications
5. plasma creatinine >2.5 mg/dl
6. elevation of liver enzymes to more that twice the upper normal limit
7. plasma potassium levels >5.5 mg/dl

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Aldosteron blokade, Arterial stiffness, Glucose homeostasis	Spironolactone	-

Trial Locations

Locations (1)

Wolfson Medical Center; 🇮🇱 Holon, Israel