Can Modern Urinary Markers be Used as Markers for Acute Kidney Failure Due to Stone Obstruction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 53
- 试验地点
- 1
- 主要终点
- urinary markers behavior
研究概览
简要总结
Renal colic is usually caused from an obstructing stone along the ureter. Some of the patients present with a high level of creatinin in the blood, even though there is a normal functioning contralateral kidney. Furthermore creatinin is not an ideal marker for renal function during acute changes.
Several works have shown that modern urinary markers such as NGAL (neutrophil gelatinase-associated lipocalin), KIM-1 (Kidney Injury Molecule-1) and others rise earlier and are much more sensitive for kidney insult. There is a lack of research on their role in acute kidney obstruction
详细描述
The study population will include 100 men and women that will be recruited during the upcoming year, with a follow up of up to 3 months.
The study population will be divided into 2 groups:
- The stone group: about 80 patients, aged 18-65, with normal creatinine for the past year that presented in our ER because of renal colic, and their imaging shows a ureteral stone.
- The non-stone group: about 20 patients that present in our department for elective surgery not related to stones or bladder outlet obstruction.
The stone group:
---------------- In the ER the patients will be examined, undergo blood and urine workup and imaging as usual. If they are applicable according to our inclusion and exclusion criteria and admitted and they will be included in our stone group. After signing an informed consent, either as patients with a ureteral stone and normal creatinine or as patients with a ureteral stone and an abnormal creatinine, Their urine sample will be sent for the urinary markers: NGAL, KIM-1, ENdothelin and Cystatin C.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •patients with stones in the contralateral ureter
- •patients who underwent renal surgery
- •patients who took NSAID's (nonsteroidal antiinflammatory drugs) in the past week before presentation
- •patients woth anatomical defects in the kidneys
结局指标
主要结局
urinary markers behavior
时间窗: one week
What is the level of the urine markers NGAL, KIM-1, ENdothelin and Cystatin C at presentation and 48 hours after presentation, in patients presenting with renal colic in the ER
次要结局
- following the markers in patients whose kidneys were drained(one week)