Raspberries and Postprandial Metabolism

Not Applicable

Completed

• Conditions: Type 2 Diabetes Mellitus
• Interventions: Other: Raspberries

• Registration Number: NCT03403582
• Lead Sponsor: Oklahoma State University

Brief Summary

Raspberries are high in several phytochemicals, vitamin C and B vitamins and have been shown to be potent antioxidants and anti-inflammatory agents. However, human interventional studies reporting the effects of raspberries in obesity, T2DM and associated oxidative stress and inflammation are limited. Aims, objectives and methods:

Aim 1: To assess the effects of raspberries in postprandial glycemia and lipemia following a high-fat fast-food style meal challenge versus control group Objectives: to execute this aim, the investigators will conduct analyses of serum glucose, insulin and lipids (total cholesterol, LDL-cholesterol, triglycerides, VLDL-cholesterol and HDL-cholesterol) at fasting (baseline) and at postprandial 1,2,4 hours of high-fat, fast food style breakfast consumption. The investigators will also calculate homoeostasis model assessment of insulin resistance (HOMA-IR) at these time points using serum glucose and insulin values.

Aim 2: To assess the effects of raspberries in postprandial vascular functions (blood pressure and artery elasticity) and inflammation following a high-fat fast food style meal challenge versus control group

Objectives: to execute this aim, the investigators will measure C-reactive protein (CRP) and the following parameters of vascular function associated with CVD at fasting (baseline) and at postprandial 1,2,4 hours of high-fat, fast food style breakfast consumption:

* systolic blood pressure and diastolic blood pressure

* large artery elasticity index and small artery elasticity index

* systemic vascular resistance

Detailed Description

Not available

Study Timeline

• Study Start: 2014-12
• Primary Completion: 2016-09
• Study Completion: 2017-12
• Status Verified: 2018-01
• Study First Submitted: 2018-01-05
• Study First Submitted QC: 2018-01-10
• Last Update Submitted: 2018-01-10
• Study First Posted: 2018-01-18
• Last Update Posted: 2018-01-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• type 2 diabetes

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Exclusion Criteria

• not having type 2 diabetes

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Raspberry arm	Raspberries	A high-fat break fast meal with raspberries (250g frozen)

Primary Outcome Measures

Name	Time	Method
Postprandial blood glucose	postprandial 4 hours	Postprandial blood glucose will be measured at fasting, 1, 2 and 4 hours following meals with or without raspberries
Postprandial blood lipids	postprandial 4 hours	Postprandial blood lipids will be measured at fasting, 1, 2 and 4 hours following meals with or without raspberries

Secondary Outcome Measures

Name	Time	Method
Postprandial inflammation	postprandial 4 hours	Postprandial C-reactive protein and interleukins will be measured at fasting, 1, 2 and 4 hours following meals with or without raspberries

Trial Locations

Locations (1)

Oklahoma State University; 🇺🇸 Stillwater, Oklahoma, United States