Fat Absorption and Metabolism After Roux-en-Y Gastric Bypass
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Area under the curve of plasma triacylglycerol
研究概览
简要总结
Using intravenous and oral administration of stable isotope tracers, we will investigate the importance of altered fat absorption and altered whole body fat metabolism for the reduced postprandial systemic TAG concentrations in non-diabetic patients in weight stable phase after RYGB.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age > 18 years
- •RYGB > 12 months prior to inclusion
- •Weight stable (± 3 kg during the last month)
- •HbA1c < 48 mmol/mol before surgery, and no history of diabetes
- •HbA1c < 48 mmol/mol and fasting plasma glucose < 6.1 mmol/l at inclusion
- •Inclusion criteria, CON
- •Age > 18 years
- •No former bariatric surgery
- •Weight stable (± 3 kg during the last month)
- •HbA1c < 48 mmol/mol, fasting plasma glucose < 6.1, and no history of diabetes
排除标准
- •Thyrotoxicosis or inadequately treated hypothyreosis
- •Haemoglobin < 6.5 mmol/l at inclusion
- •Pregnancy (pregnancy test in fertile woman before enrolment) or breast feeding
- •Medication affecting the planned examinations which cannot be paused during the study period.
- •Adherence to extreme diets with excessively high or low contributions from certain macronutrients (e.g. ketogenic diet)
- •Complications restricting eating behavior (e.g. postprandial hypoglycemia, vomiting or strictures)
- •MR contraindications
研究组 & 干预措施
Roux-en-Y gastric bypass operated participants
Roux-en-Y gastric bypass operated participants in weight stable phase > 1 year from surgery
干预措施: Metabolic test (Other)
Roux-en-Y gastric bypass operated participants
Roux-en-Y gastric bypass operated participants in weight stable phase > 1 year from surgery
干预措施: DXA-scan (Other)
Roux-en-Y gastric bypass operated participants
Roux-en-Y gastric bypass operated participants in weight stable phase > 1 year from surgery
干预措施: MRS (Other)
Roux-en-Y gastric bypass operated participants
Roux-en-Y gastric bypass operated participants in weight stable phase > 1 year from surgery
干预措施: Feces collection (Other)
Control participants
Age, sex, and BMI-matched un-operated participants.
干预措施: Metabolic test (Other)
Control participants
Age, sex, and BMI-matched un-operated participants.
干预措施: DXA-scan (Other)
Control participants
Age, sex, and BMI-matched un-operated participants.
干预措施: MRS (Other)
Control participants
Age, sex, and BMI-matched un-operated participants.
干预措施: Feces collection (Other)
结局指标
主要结局
Area under the curve of plasma triacylglycerol
时间窗: 6 hours
During a high-fat liquid mixed meal test
次要结局
- Recovery of oral stable triacylglycerol isotope tracer in feces(4 days)
研究者
Morten Gadegaard Hindsø, MD
Principal Investigator
Hvidovre University Hospital