Resistance Exercise Training in Chronic Kidney Disease

Not Applicable

Completed

• Conditions: Chronic Kidney Disease

• Registration Number: NCT03120416
• Lead Sponsor: University of Illinois at Chicago

Brief Summary

The investigators aim to evaluate the feasibility of a resistance exercise training program among individuals with CKD and its impact on endothelial and vascular function.

Detailed Description

Resistance exercise training has been shown to improve cardiovascular health including endothelial function in general populations, but studies in patients with chronic kidney disease (CKD) are limited. The investigators aim to evaluate the feasibility and acceptability of a resistance exercise training program among individuals with CKD and its impact on endothelial and vascular function as measured by brachial artery flow-mediated dilation, pulse-wave velocity and carotid artery stiffness. To accomplish this goal the investigators propose to conduct a 12-week pilot randomized controlled trial of twice a week resistance exercise training among 32 adults with CKD. The results of this study will inform the design and implementation of a larger trial evaluating the impact of resistance exercise training on adverse outcomes in patients with CKD including CKD progression.

Study Timeline

• Study Start: 2017-01-25
• Study First Submitted: 2017-04-04
• Study First Submitted QC: 2017-04-14
• Study First Posted: 2017-04-19
• Primary Completion: 2018-07-31
• Study Completion: 2018-07-31
• Status Verified: 2019-04
• Last Update Submitted: 2019-04-15
• Last Update Posted: 2019-04-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• CKD stage 3 or 4 (eGFR 15-60 ml/min/1.73m2)

Exclusion Criteria

• Currently institutionalized
• Kidney transplant or dialysis
• NY Heart Association class 3-4 heart failure
• Dementia or cognitive impairment
• Unstable angina or coronary revascularization within the last 3 months
• Uncontrolled arrhythmia
• Severe chronic lung disease
• Orthopedic, neurologic or other condition that would preclude resistance exercise training
• Pregnancy
• Uncontrolled hypertension (systolic > 160 mmHg and diastolic >90 mmHg)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Endothelial function	3 months	Measured by brachial artery flow-mediated dilation (FMD)

Secondary Outcome Measures

Name	Time	Method
Objectively measured physical activity	3 months	Assessed by a physical activity monitor (ActiGraph GT3X+)
Serum LDL-cholesterol	3 months	Measured using standard procedures
Vascular function	3 months	Measured by pulse wave velocity
Carotid artery stiffness	3 months	Measured by non-invasive ultrasound
Systolic blood pressure	3 months	Measured using standard procedures
Muscle strength	3 months	Assessed by the amount of weight lifted in a single chest press and leg press (1 RM).
Self-reported physical activity	3 months	Assessed by the MESA (Multiethnic Study of Atherosclerosis) Typical Week Physical Activity Survey
Serum HDL-cholesterol	3 months	Measured using standard procedures

Trial Locations

Locations (1)

University of Illinois at Chicago; 🇺🇸 Chicago, Illinois, United States