Effect of Resistance Exercise Training on Endothelial Function and Cardiovascular Risk Factors in Patients With Chronic Kidney Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 2
- 主要终点
- Endothelial function
研究概览
简要总结
The investigators aim to evaluate the feasibility of a resistance exercise training program among individuals with CKD and its impact on endothelial and vascular function.
详细描述
Resistance exercise training has been shown to improve cardiovascular health including endothelial function in general populations, but studies in patients with chronic kidney disease (CKD) are limited. The investigators aim to evaluate the feasibility and acceptability of a resistance exercise training program among individuals with CKD and its impact on endothelial and vascular function as measured by brachial artery flow-mediated dilation, pulse-wave velocity and carotid artery stiffness. To accomplish this goal the investigators propose to conduct a 12-week pilot randomized controlled trial of twice a week resistance exercise training among 32 adults with CKD. The results of this study will inform the design and implementation of a larger trial evaluating the impact of resistance exercise training on adverse outcomes in patients with CKD including CKD progression.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •CKD stage 3 or 4 (eGFR 15-60 ml/min/1.73m2)
排除标准
- •Currently institutionalized
- •Kidney transplant or dialysis
- •NY Heart Association class 3-4 heart failure
- •Dementia or cognitive impairment
- •Unstable angina or coronary revascularization within the last 3 months
- •Uncontrolled arrhythmia
- •Severe chronic lung disease
- •Orthopedic, neurologic or other condition that would preclude resistance exercise training
- •Pregnancy
- •Uncontrolled hypertension (systolic > 160 mmHg and diastolic >90 mmHg)
研究组 & 干预措施
Control
Participants randomized to the control group will be offered an educational brochure regarding exercise published by the NKF.
Resistance exercise training program
Eight exercises will be used to include large upper and lower body muscle groups. The baseline 1 repetition maximum (RM) will be used to set initial training loads. All exercise sessions will be performed under the supervision of an exercise physiologist. Vital signs and body weight will be recorded before each session. The workload during training will be adjusted to reflect 80% of the most recent 1 RM (approximately 8-12 RM set). In addition, patients' workloads will be progressively increased if the patients can lift the weight more than 12 repetitions. Participants will perform three sets of 8-12 repetitions on each machine per session.
干预措施: Resistance exercise training (Behavioral)
结局指标
主要结局
Endothelial function
时间窗: 3 months
Measured by brachial artery flow-mediated dilation (FMD)
次要结局
- Objectively measured physical activity(3 months)
- Serum LDL-cholesterol(3 months)
- Vascular function(3 months)
- Carotid artery stiffness(3 months)
- Systolic blood pressure(3 months)
- Muscle strength(3 months)
- Self-reported physical activity(3 months)
- Serum HDL-cholesterol(3 months)
研究者
Ana C. Ricardo, MD, MPH, MS
Assistant Professor of Medicine
University of Illinois at Chicago