Study to describe the processing of ropivacaine in the body when injected in the knee for pain treatment in total knee replacement surgery
Completed
- Conditions
- patients requiring unilateral total knee replacement
- Registration Number
- NL-OMON21012
- Lead Sponsor
- Sint Maartenskliniek Nijmegen
- Brief Summary
Pharmacokinetics of 400 mg ropivacaine after periarticular local infiltration analgesia for total knee arthroplasty
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
age 50-80 years
- ASA physical Health Classification I-II
Exclusion Criteria
- Placement of a surgical drain
- Contra-indications for spinal anesthesia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mean total and unbound maximum serum concentration of ropivacaine (Cmax) and mean time to total and unbound maximum serum concentration of ropivacaine (Tmax)
- Secondary Outcome Measures
Name Time Method Age, weight, height, gender, co-medication, complications and signs of systemic toxicity will be recorded.