Effect of Non Surgical Periodontal Therapy on Inflammatory Markers in Chronic Periodontitis Patients
- Conditions
- Aggressive Periodontitis
- Interventions
- Procedure: non surgical periodontal therapy
- Registration Number
- NCT05295576
- Lead Sponsor
- Future University in Egypt
- Brief Summary
The current study was performed to study levels of Il-17 and Il-18 in aggressive periodontitis patients before and after non surgical periodontal therapy
- Detailed Description
Background:host defense factors are involved in pathogenesis of chronic periodontitis so, the current study is assessing levels of Il-17 and Il-18 in chronic periodontitis patients versus periodontally healthy controls.
Subjects and methods: Fifty subjects were included; twenty five of them are diagnosed with chronic periodontitis patients and twenty five are periodontally healthy subjects. Probing depth (PD), clinical attachment level (CAL), plaque index (PI) and gingival index (GI) were recorded for all the enrolled subjects. GCF levels of Il-17 and IL-18 were analyzed by enzyme-linked immunosorbent assay (ELISA).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
- Medically free subjects .
- both genders .
- age range between 30 to 60 years old .
- Subjects with periodontal surgeries in the last 6 months.
- Subjects with prior use of antibiotics in the last 6 months.
- Smokers.
- Pregnant and lactating females were excluded.
- Lactating females.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description chronic periodontitis non surgical periodontal therapy scaling and root planing
- Primary Outcome Measures
Name Time Method measure levels of Il-17 and Il-18 in chronic periodontitis patients Change from Baseline Il-17 andIl-18 at 3 months measure levels of Il-17 and Il-18 in GCF of chronic periodontitis patients
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Future university in Egypt
🇪🇬Cairo, Egypt