Effect Of Non-Surgical Periodontal Treatment On Lipoxin a4 Levels

Not Applicable

Completed

• Conditions: Periodontitis
• Interventions: Procedure: Non-surgical periodontal treatment

• Registration Number: NCT04053660
• Lead Sponsor: T.C. ORDU ÜNİVERSİTESİ

Brief Summary

The aim of this study was to evaluate the levels of lipoxin A4 (LXA4), prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) in gingival crevicular fluid (GCF) and saliva in individuals with periodontal healthy and chronic periodontitis. In addition, the investigators evaluated the levels of these mediators after non-surgical periodontal treatment in patients with chronic periodontitis. A total of 20 subjects, 10 patients with chronic periodontitis (CP) and 10 periodontally healthy individuals were included in the study. Clinical parameters including plaque index (PI), gingival index (GI), probing depth (PD) and clinical attachment levels (CAL) were recorded. GCF and saliva samples were obtained at the beginning of the study from all individuals. GCF and saliva samples were re-collected from patients with CP at 1 month after non surgical periodontal therapy.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-10-01
• Primary Completion: 2018-12-31
• Study Completion: 2018-12-31
• Status Verified: 2019-08
• Study First Submitted: 2019-08-02
• Study First Submitted QC: 2019-08-09
• Last Update Submitted: 2019-08-09
• Study First Posted: 2019-08-12
• Last Update Posted: 2019-08-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Have at least 20 natural teeth, excluding third molars.
• Chronic periodontitis patients had at least two non-adjacent sites per quadrant with probing depth (PD) ≥ 5 mm and clinical attachment level (CAL) ≥ 5 mm with gingival inflammation, and alveolar bone loss affecting >30% of the teeth, as detected on clinical and radiographical examinations.
• Periodontally healthy control group had no sign of gingival inflammation, no PD > 3mm and no evidence of attachment or bone loss.

Exclusion Criteria

• History of systemic disease.
• Regular use of any drugs which can effect the immune system or inflammatory response in the 6 months preceding the start of the study.
• Periodontal treatment during last 6 months that could affect periodontal status.
• Smoking.
• History of radiotherapy or chemotherapy.
• Ongoing orthodontic treatment.
• Aggressive periodontitis.
• Current pregnancy, lactation or menopause.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Chronic Periodontitis	Non-surgical periodontal treatment	Patients with chronic periodontitis

Primary Outcome Measures

Name	Time	Method
Lipoxin A4 levels	1st month	change of gingival crevicular fluid and salivary Lipoxin A4 levels from baseline at 1st month

Secondary Outcome Measures

Name	Time	Method
Prostaglandin E2 levels	1st month	change of gingival crevicular fluid and salivary Prostaglandin E2 levels from baseline at 1st month
Leukotriene B4	1st month	change of gingival crevicular fluid and salivary Leukotriene B4 levels from baseline at 1st month

Trial Locations

Locations (1)

Ordu University; 🇹🇷 Ordu, Turkey