Effect of chemotherapy and ionising radiation on sperm nuclear and mitochondrial DNA: Can pre-treatment with GnRH Agonists reverse these effects?

Completed

• Conditions: rological and Genital Diseases; Urological and Genital Diseases

• Registration Number: ISRCTN77877146
• Lead Sponsor: Record Provided by the NHSTCT Register - 2005 Update - Department of Health (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-09-30
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 0

Inclusion Criteria

Patients will be referred from tertiary referral centres in Birmingham. These will include principally the Queen Elizabeth Hospital in Edgbaston, Selly Oak Hospital and the Dept of Haematology, Heartlands Hospital. They will have been referred for sperm storage to prior to chemo or radiotherapy mainly in cases of malignant disease but also in other conditions e.g. treatment of nephrotic syndrome. Patients will be randomised to treatment groups at the point of intention to treat.

Exclusion Criteria

Not provided at time of registration

Study & Design

• Study Type: Interventional
• Study Design: Not specified