Physiological Assessment of the Endothelium - Circadian Rhythm and Role of the Sympathetic Nervous System
- Conditions
- Endothelial Function
- Registration Number
- NCT01713374
- Lead Sponsor
- Johannes Gutenberg University Mainz
- Brief Summary
The purpose of this study is to determine whether interventions aimed at increasing sympathetic tone modify endothelial function measures as assessed by the measurement of flow-mediated dilation (FMD) and constriction (FMC). The investigators hypothesize that the three interventions under study will increase FMC while causing a blunting in FMD.
Further, the investigators plan to study the circadian variability of FMC and FMD. The investigators hypothesize a peak of FMD in the late hours of the day and a peak of FMC in the early hours.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 40
- healthy volunteers with no cardiovascular risk factor, no current disease, normal laboratory parameters and ECG.
- any active disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Change in FMD in response to sympathetic activation Change in FMD before versus 1 Minute after begin of intervention Flow-mediated dilation will be measured at rest and during each of the interventions.
- Secondary Outcome Measures
Name Time Method Change in FMC during sympathetic activation Change in FMC before versus 1 minute after begin of each intervention Change in Flow-mediated constriction induced by each of the interventions.
Trial Locations
- Locations (1)
University Medical Center Mainz
🇩🇪Mainz, Rheinland Pfalz, Germany
University Medical Center Mainz🇩🇪Mainz, Rheinland Pfalz, Germany