Studies on the Physiological Meaning of Flow-mediated Constriction, Flow-mediated Dilatation and Vasomotion/Flowmotion: Circadian Variability and Role of the Sympathetic Nervous System.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Endothelial Function
- Sponsor
- Johannes Gutenberg University Mainz
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Change in FMD in response to sympathetic activation
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
The purpose of this study is to determine whether interventions aimed at increasing sympathetic tone modify endothelial function measures as assessed by the measurement of flow-mediated dilation (FMD) and constriction (FMC). The investigators hypothesize that the three interventions under study will increase FMC while causing a blunting in FMD.
Further, the investigators plan to study the circadian variability of FMC and FMD. The investigators hypothesize a peak of FMD in the late hours of the day and a peak of FMC in the early hours.
Investigators
Tommaso Gori
Professor
Johannes Gutenberg University Mainz
Eligibility Criteria
Inclusion Criteria
- •healthy volunteers with no cardiovascular risk factor, no current disease, normal laboratory parameters and ECG.
Exclusion Criteria
- •any active disease
Outcomes
Primary Outcomes
Change in FMD in response to sympathetic activation
Time Frame: Change in FMD before versus 1 Minute after begin of intervention
Flow-mediated dilation will be measured at rest and during each of the interventions.
Secondary Outcomes
- Change in FMC during sympathetic activation(Change in FMC before versus 1 minute after begin of each intervention)