Renin-angiotensin-aldosterone System (RAAS) Blockade and Contrast Induced Nephropathy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 主要终点
- change in eGFR from baseline to 48-72 hours following the exposure to the contrast.
研究概览
简要总结
The aim of the current study is to evaluate prospectively whether concomitant administration of renin-angiotensin-aldosterone system (RAAS) blockers (namely ACE-I and ARBs') influence the change in estimated glomerular filtration rate or GFR (eGFR) after administration of contrast media in patients undergoing non-emergent coronary angiography.
详细描述
Contrast-induced nephropathy (CIN) is defined as an absolute or relative increase in serum creatinine compared to the baseline values, together with exposure to a contrast agent and exclusion of alternative explanations for renal impairment. Most frequently the renal impairment develops 48 hours post exposure. Although RAAS blocking agents are widely used among patients requiring contrast studies, data regarding the effect of these agents on the development of CIN are sparse and inconsistent. Patients undergoing percutaneous coronary intervention are frequently treated with RAAS blocking agents. Despite the not infrequent occurrence of CIN following percutaneous coronary intervention (PCI) no guidelines are available on the topic of the cessation of the RAAS inhibitors prior to the procedure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age > 18 years,
- •chronic therapy with ACE-I and/or ARBs' (confirmed by electronic records in their medical file) and
- •planned coronary angiography
排除标准
- •chronic utilization of NSAIDS and Cox-2 selective inhibitors,
- •chronic treatment with mineralocorticosteroid receptor blocker, and
- •administration of contrast within 14 days prior to the enrollment.
结局指标
主要结局
change in eGFR from baseline to 48-72 hours following the exposure to the contrast.
时间窗: 48 AND 72 HOURS AFTER EXPOSURE TO CONTRAST MEDIA
次要结局
未报告次要终点