NCT01071642已完成不适用
The Influence of Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Renal Function in Patients Undergoing Non-emergent Coronary Angiography
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Change in eGFR from baseline to 48 hours following the exposure to the contrast.
研究概览
简要总结
The aim of the current study is to evaluate prospectively whether concomitant administration of RAAS blockers (namely ACE-I and ARBs') influence the change in estimated GFR (eGFR) after administration of contrast media in patients undergoing non-emergent coronary angiography.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age>18 years
- •Subjects on chronic therapy with ACE-I and/or ARBs' (confirmed by electronic records in their medical file)
- •Subjects planned to undergo non-emergent coronary angiography.
- •Signed informed consent
排除标准
- •eGFR<30 ml/min at baseline
- •Chronic utilization of NSAIDS and Cox-2 selective inhibitors
- •Chronic treatment with mineralocorticosteroid receptor blocker
- •Systolic blood pressure<90 mmHg
- •Planned staged (repeated) procedure within 48 hours
- •Administration of contrast within 14 days prior to the enrollment
- •contraindication to stop ACE-I or ARB'S
研究组 & 干预措施
group b
Active Comparator
干预措施: stop ace-i/arb 24 h before procedure and restarted 24 hours after the procedure (Drug)
group c
Active Comparator
干预措施: ACE/ARB stopped 24 hours before procedure and start immediately after (Drug)
结局指标
主要结局
Change in eGFR from baseline to 48 hours following the exposure to the contrast.
时间窗: 48 hours after exposure to the contrast
次要结局
- 1. Rate of eGFR decrease>25% from the baseline, 2. Length of hospitalization,(48-72 hours after exposure to contrast)
研究者
Talya Wolak
senior doctor internal medicine department
Soroka University Medical Center
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Renin-angiotensin-aldosterone System (RAAS) Blockade and Contrast Induced NephropathyRadiographic Contrast Agent NephropathyNCT01525888Soroka University Medical Center100
已完成
2 期
Effects of Angiotensin-Converting Enzyme Inhibitor (Ramipril) Therapy on Blood Vessel InflammationCoronary DiseaseAtherosclerosisVasculitisNCT00005928National Heart, Lung, and Blood Institute (NHLBI)25
终止
不适用
ACE-Inhibitor Effects on Total Hip and Knee Arthroplasty PatientsAdverse Effects of Angiotensin-converting-enzyme InhibitorsHypotensionNCT01867047Duke University59
已完成
4 期
Effects of Aceis on Peritoneal Protein Loss and Solute Transport in pd PatientsDisorders Associated With Peritoneal DialysisNCT01575652Turkish Nephrology Association43
已完成
不适用
Effect of angiotensin-converting enzyme inhibitors on systemic inflammation and myocardial sympathetic innervation in normotensive patients with type two diabetes mellitusType two Diabetes Mellitus (DM)Nutritional, Metabolic, EndocrineDiabetes mellitusISRCTN76608550Heraklion University Hospital (Greece)62