A randomised, comparative effectiveness study of COMPLETE versus culprit-only revascularization strategies to treat multi-vessel disease after primary percutaneous coronary interventions (PCI) for ST-segment elevation myocardial infarction

Population Health Research Institute (Canada)0 个研究点目标入组 4,041 人开始时间: 2014年1月16日最近更新: 2021年4月26日

适应症

试验速览

•1. Men and women within 72 hours after successful PCI (preferably using a drug-eluting stent) to the culprit lesion for STEMI. PCI for STEMI can be either primary PCI or rescue PCI for failed fibrinolysis or a pharmacoinvasive strategy where PCI is performed routinely 3-12 hours after initiation of fibrinolysis
•2. Multi-vessel disease defined as at least 1 additional non-infarct related coronary artery lesion that is at least 2.5 mm in diameter that has not been stented as part of the primary PCI and that is amenable to successful treatment with PCI and has
•2.1. at least 70% diameter stenosis (visual estimation) or
•2.1. at least 50% diameter stenosis (visual estimation) with fractional flow reserve less than or equal to 0.80

•1. Planned revascularisation of non-culprit lesion(s)
•2. Planned surgical revascularisation
•3. Non-cardiovascular co-morbidity reducing life expectancy to less than 5 years
•4. Any factor precluding 5 year follow up.
•5. Prior coronary artery bypass graft (CABG) surgery.

发起方

Population Health Research Institute (Canada)