The Investigation of the Roles of Prostanoids in Patients With Sleep Apnea Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 46
- 试验地点
- 2
- 主要终点
- metabolites of arachidonic acid in the urine and blood
研究概览
简要总结
The purpose of this study is to evaluate the relationships between prostanoids and various outcomes such as sleep disturbance, hypertension and arteriosclerosis in patients with sleep apnea syndrome(SAS). In the patients introduced to continuous positive airway pressure(CPAP) treatment, the effects of CPAP are also evaluated.
详细描述
SAS is characterized by abnormality during sleep and hypoxemia from apnea and hypopnea, followed by systemic inflammation and organ dysfunction like cardiovascular diseases. Systemic inflammation causes the activation of arachidonic acid metabolism, producing prostaglandins (PGs) and leukotrienes (LTs). In addition, significant relationships between PGD2 and PGE2 and sleep, PGF2α and hypertension, PGI2 and thromboxane and platelet aggregation and so on are reported. Therefore, it is hypothesized that many prostanoids affect the pathophysiology of SAS. However, the relationships between prostanoids and clinical outcomes in patients with SAS are unknown. Although CPAP is the major treatment of SAS, the effects of CPAP on prostanoids are not known, either. Thus, the purpose of this study is to evaluate those relationships.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects hospitalized in Kyoto University Hospital for careful examination of SAS
排除标准
- •Subjects with severe respiratory diseases, severe heart diseases, severe vascular diseases, or severe diabetes mellitus.
- •Subjects taking nonsteroidal anti-inflammatory drugs, steroids or immunosuppressants.
研究组 & 干预措施
CPAP
the subjects introduced with CPAP treatment
干预措施: CPAP treatment (Device)
结局指标
主要结局
metabolites of arachidonic acid in the urine and blood
时间窗: 3 months
次要结局
- Polysomnography measurements(3 months)
- Sleepiness and health-related quality of life(3 months)
- Blood pressure and pulse rate(3 months)
- Endothelial dysfunction(3 months)
- Platelet aggregation(3 months)
- Cardiac and neck echo cardiography(3 months)
研究者
Toru Oga
Respiratory Care and Sleep Control Medicine, Kyoto University, Graduate School of Medicine
Kyoto University, Graduate School of Medicine