Effects of Mental Stimulation in Patients With Mild Cognitive Impairment
Phase 2
Completed
- Conditions
- Mild Cognitive Impairment (MCI)
- Interventions
- Behavioral: mentally stimulating activities
- Registration Number
- NCT01212692
- Lead Sponsor
- Johns Hopkins University
- Brief Summary
The purpose of this study is to learn if activities that challenge the brain (mentally stimulating activities) can improve memory and other types of thinking in patients with Mild Cognitive Impairment. The study will compare the effects of different methods of mental stimulation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 63
Inclusion Criteria
- ≥ 50 years of age
- meet criteria for amnestic-Mild Cognitive Impairment (MCI)
- have capacity to give informed consent
- have capacity to complete assessment measures
Exclusion Criteria
- history of drug or alcohol dependence
- severe psychiatric conditions associated with psychosis (e.g., schizophrenia)
- recent stroke
- clinical diagnosis of probable Alzheimer's Disease
- history of seizure disorder, serious head trauma, or other medical, psychiatric, or neurological conditions associated with significant cognitive impairment (e.g., Parkinson's Disease, Korsakoff's, HIV)
- current use of Alzheimer's Disease medications (e.g., cholinesterase inhibitors, memantine)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Mentally stimulating activities mentally stimulating activities - Mentally stimulating activities- other mentally stimulating activities -
- Primary Outcome Measures
Name Time Method Self-Ordered Pointing Task baseline Trail-Making 9 months post-intervention Timed Instrumental Activities of Daily Living 9 months post-intervention Rey Auditory Verbal Learning Test 9 months post-intervention Self-ordered pointing task 9 months post-intervention
- Secondary Outcome Measures
Name Time Method Clinical Dementia Rating Scale baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention Digit Symbol Substitution Test baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention Digit Span baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention Verbal Fluency Test baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention N-Back baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention Instrumental Activities of Daily Living baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention Neuropsychiatric Inventory baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention Multifactorial Memory Questionnaire baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention Geriatric Depression Scale baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention Recollection Task baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention Rivermead Behavioral Memory Test baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention Functional Capacities for Activities of Daily Living baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention
Trial Locations
- Locations (1)
BPRU, Johns Hopkins Bayview Medical Center
🇺🇸Baltimore, Maryland, United States