Evaluation of the effect of Levetiracetam on cognitive impairment in patients with MS

Phase 3

Recruiting

• Conditions: Relapsing-remitting multiple sclerosis.; Multiple sclerosis

• Registration Number: IRCT20210707051810N2
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 1 November 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 88

Inclusion Criteria

Patients with relapsing-remitting multiplesclerosis age between 18 and 60 years
Have a minimum education to perform cognitive tests
RRMS (2017 Revisions of the McDonald” Criteria )
At least 2 years have passed since the definitive diagnosis of the disease
Receiving first-line injectable and oral disease modifying drugs (interferon beta, glatiramer acetate, triflunomide and dimethyl fumarate)
Type and dose of DMD have not changed in the last six months
Have not received corticosteroids in last 30 days
Have not relapse in the last 60 days
Expanded Disability Status Scale (EDSS) scores of 5.5 or less
Voluntarily participated in the present study

Exclusion Criteria

History of drug or alcohol abuse in the last six months
Pregnancy and lactation
Having any acute or major mental disorder that is not under control (type of medication and amount of use in the last three months is constant)
Having any seizure disorder
History of any suicide attempt
Chronic kidney disease (Estimated glomerular filtration rate less than 60 ml / min)
Diabetes, hypothyroidism and anemia that is not under control
Concomitant use of drugs that may affect cognitive function, such as antipsychotics, modafinil, methylphenidate, amphetamine and amphetamine-like compounds, tricyclic antidepressants and anticonvulsants other than gabapentin and pregabalin, benzodiazepines other than as sleeping pills Avar (if the dose and method of medication do not change in the last three months and during the study will not be prohibited).

Study & Design

• Study Type: interventional
• Study Design: Not specified