Effect of Transfusion of Plasma on Endothelial During Liver Transplantation

Not Applicable

Recruiting

• Conditions: End Stage Liver DIsease; Liver Transplantation
• Interventions: Diagnostic Test: blood sample; Biological: fresh frozen plasma

• Registration Number: NCT04107883
• Lead Sponsor: Beijing Chao Yang Hospital

Brief Summary

To study the effects of plasma transfusionon during liver transplantation on endothelial condition and short-term outcome in patients with end-stage liver disease.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-09-20
• Study First Submitted QC: 2019-09-26
• Study First Posted: 2019-09-27
• Study Start: 2023-10-01
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-21
• Last Update Posted: 2023-11-24
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Child A/B cirrhosis
• patients who undergo the first OLT
• Informed and consented
• complete follow-up
• cooperate with treatment

Exclusion Criteria

• re-transplant
• combined liver and other organ transplantation
• BMI≥30Kg/m2
• patients with hypertension, diabetes, coronary heart disease, chronic renal insufficiency, preoperative pulmonary infection, pleural effusion
• acute liver failure

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
control group	blood sample	perform artificial colloidal solution transfusion during anhapetic phase.
anhapetic group	fresh frozen plasma	Perform plasma transfusion during anhapetic phase.
anhapetic group	blood sample	Perform plasma transfusion during anhapetic phase.

Primary Outcome Measures

Name	Time	Method
endothelial glycocalyx layer shedding markers	24 hours	plasma concentration of endothelial glycocalyx layer shedding markers

Secondary Outcome Measures

Name	Time	Method
inflammatory cytokines	24 hours	levels of inflammatory cytokines

Trial Locations

Locations (1)

Capital Medical University Affiliated Beijing Chaoyang Hospital; 🇨🇳 Beijing, Beijing, China