Spleen Preserving Surgery for Splenic Hydatidosis: A Cohort Study on Short and Long-Term Outcomes

Completed

• Conditions: Spleen-Preserving Surgery; Hydatid Disease; Minimally Invasive Surgery; Echinococcus Granulosus Infection

• Registration Number: NCT06289816
• Lead Sponsor: Yarmouk University

Brief Summary

This retrospective cohort study examines the effectiveness of minimally invasive spleen-preserving surgeries compared to total splenectomy for treating primary splenic hydatidosis in Jordan. Covering 18 patients from January 2015 to June 2021, the research highlights similar recurrence rates between both surgical approaches, emphasizing the benefits of spleen preservation in maintaining immune function and reducing septic risks, particularly in pediatric patients.

Detailed Description

The study delves into a detailed analysis of 18 cases of primary splenic hydatid cysts treated through spleen-preserving surgeries-laparoscopic partial splenectomy, cystectomy, and cyst deroofing-augmented by albendazole therapy. It presents a comprehensive comparison based on patient demographics, symptoms, surgical details, and outcomes, including complications and recurrence rates. Findings reveal no significant statistical difference in recurrence rates between spleen-preserving methods and total splenectomy, suggesting the viability of less invasive approaches for managing this condition effectively while preserving spleen functionality and minimizing post-operative complications. The study underlines the need for individualized treatment plans and further research with larger cohorts.

Study Timeline

• Study Start: 2015-01-01
• Primary Completion: 2021-06-30
• Study Completion: 2021-06-30
• Status Verified: 2024-02
• Study First Submitted: 2024-02-24
• Study First Submitted QC: 2024-02-24
• Last Update Submitted: 2024-02-24
• Study First Posted: 2024-03-04
• Last Update Posted: 2024-03-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• Adult patients (age 14 years or older).
• Diagnosed exclusively with primary, non-recurrent splenic hydatid cysts.

Exclusion Criteria

• Children under 14 years of age.
• Patients in late pregnancy.
• Individuals with recurrent cysts.
• Cases with extra-splenic involvement.
• Patients with less than two years of postoperative follow-up.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of Postoperative Short-Term Complications	Up to 1 month post-operation	The measure focuses on the incidence and nature of short-term complications following spleen-preserving surgeries compared to total splenectomy. Short-term complications may include infection, bleeding, or any other immediate post-surgical issues that impact recovery.
Incidence of Postoperative Long-Term Complications	Up to 2 years post-operation	This measure assesses the long-term complications associated with spleen-preserving surgeries versus total splenectomy. Specifically, it examines the recurrence of hydatid cysts as a significant long-term complication.

Trial Locations

Locations (1)

Anas Aljaiuossi; 🇯🇴 Irbid, Jordan