Study on Clinical Outcome of Vascular Inflow Occlusion in Open Liver Resection

Not Applicable

Completed

• Conditions: Hepatectomy
• Interventions: Procedure: Intermittent Pringle maneuver

• Registration Number: NCT00730743
• Lead Sponsor: Chinese University of Hong Kong

Brief Summary

This study aims to evaluate whether applying inflow vascular occlusion in modern liver resection is associated with better clinical outcome.

Eligible patients are randomly assigned to the two surgical techniques: with or without the application of inflow vascular occlusion.

Patients outcome including liver function recovery, operative time and blood loss are compared.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-05
• Study First Submitted: 2008-08-06
• Study First Submitted QC: 2008-08-06
• Study First Posted: 2008-08-08
• Primary Completion: 2011-05
• Study Completion: 2011-08
• Status Verified: 2015-02
• Last Update Submitted: 2015-02-02
• Last Update Posted: 2015-02-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 126

Inclusion Criteria

• Age > 18 years
• Child-Pugh Class A or B

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Exclusion Criteria

• Informed consent not available
• Presence of portal vein thrombosis, portal vein tumor thrombus, or previous portal vein embolisation
• Presence of hepatic artery thrombosis, previous transarterial therapy like TACE, or transarterial internal radiation
• When portal vein resection is anticipated
• Emergency hepatectomy
• Ruptured hepatocellular carcinoma
• Rehepatectomy (repeated liver resection)
• Adhesion or anatomical variation that preclude safe and successful application of Pringle maneuver
• When concomitant bowel or bile duct resection is anticipated

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	Intermittent Pringle maneuver	Intermittent clamp group

Primary Outcome Measures

Name	Time	Method
Operative blood loss	From skin incision to completion of operation
Operative time	From skin incision to completion of operation

Secondary Outcome Measures

Name	Time	Method
Operative morbidity and mortality	From date of operation to 30-day after operation
Recovery of liver function	From date of operation to date of discharge

Trial Locations

Locations (1)

Prince of Wales Hospital; 🇨🇳 Hong Kong, China