inflAmmatory maRkers in Blood and Thrombus Aspirated From Patients With acutE myocaRdial Infarction With St-segment elevAtion

• Conditions: Patients Admitted With the Diagnosis of ST-elevation Acute Coronary Syndrome
• Interventions: Other: Biomarkers to analyze both intracoronary thrombi as blood

• Registration Number: NCT01757886
• Lead Sponsor: Fundación Canaria Rafael Clavijo para la Investigación Biomédica

Brief Summary

The prognostic value of inflammatory markers in acute coronary syndrome has been extensively demonstrated, however it is still unknown whether there is an association between circulating and local (thrombus) inflammatory molecules, and the subset of molecules that provide better prognostic information in patients with ST-elevation acute coronary syndrome.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-11
• Primary Completion: 2012-11
• Status Verified: 2012-12
• Study First Submitted: 2012-12-22
• Study First Submitted QC: 2012-12-22
• Last Update Submitted: 2012-12-22
• Study First Posted: 2012-12-31
• Last Update Posted: 2012-12-31
• Study Completion: 2013-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• They include patients of both sexes, without limits of age, with a diagnosis of STEMI within 12 hours after the beginning of symptoms. ST-elevation myocardial infarction was defined in the presence of symptoms consistent, persistent elevation (> 20 min) ST segment ≥ 1 mm in at least two contiguous leads or in the presence of left bundle branch block presumably new onset and cardiac troponin I elevation

Exclusion Criteria

• Injury significant common core of left coronary artery (stenosis greater than or equal to 50% of the vessel lumen).
• Pre-Fibrinolysis percutaneous coronary intervention.
• Previous coronary bypass surgery.
• Thyrotoxicosis.
• Having an inflammatory systemic or local inflammatory process.
• Malignant neoplasm.
• Any disease that seriously compromise the prognosis and / or systemic inflammatory response generated.
• No thrombotic material obtained in the thrombus or insufficient for performing biochemical determinations.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
ST-elevation acute coronary syndrome	Biomarkers to analyze both intracoronary thrombi as blood	ARTERY is a prospective, multicenter, which will include patients admitted with the diagnosis of ST-elevation acute coronary syndrome and thrombus aspiration is performed during primary angioplasty

Primary Outcome Measures

Name	Time	Method
The primary objective of the study is to find out whether there is an association between certain inflammatory markers in blood and intracoronary thrombus and whether these markers are associated with the composite of all-cause mortality	one year

Trial Locations

Locations (1)

Hospital Universitario de Canarias; 🇪🇸 La Laguna, Tenerife, Spain