Efficacy of Twice Weekly Hemodialysis in Patients With Residual Kidney Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 58
- 试验地点
- 6
- 主要终点
- QOL: Kidney Disease Quality of Life (KDQOL36)
研究概览
简要总结
The study will determine the efficacy of twice weekly hemodialysis in patients with residual kidney function.
详细描述
Hemodialysis patients who have residual kidney function will undergo two 4-week study (twice weekly versus thrice weekly hemodialysis) using a cross-over design. Blood, urine, and dialysate samples will be collected at the end of each study period to determine adequacy of treatment and to assess uremic solute levels. Participants will complete quality of life questionnaires and cognitive paper tests.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients on hemodialysis who have residual kidney function with residual urea clearance (Kru) >2.5 mL/min.
- •been on hemodialysis for at least 3 months.
- •adherence to regular dialysis treatments.
排除标准
- •inability to achieve adequate hemodialysis.
- •planned revision of hemodialysis vascular access.
- •hospitalized within the past 2 months.
结局指标
主要结局
QOL: Kidney Disease Quality of Life (KDQOL36)
时间窗: 4 weeks
Kidney Disease Quality of Life: Health-related quality of life, with higher scores being better. Minimum is 0, maximum is 100.
QOL: Kidney Disease Quality of Life (KDQOL36)
时间窗: 4 weeks
Kidney Disease Quality of Life: Health-related quality of life, with higher scores being better. Minimum is 0, maximum is 100.
次要结局
- Solute Concentration(4 weeks)
- Symptom(4 weeks)
- Trail B Making Test(4 weeks)
- Digit Symbol Substitution Test(4 weeks)
- Solute Concentration(4 weeks)
- Symptom(4 weeks)
- Trail B Making Test(4 weeks)
- Digit Symbol Substitution Test(4 weeks)
研究者
Tammy Sirich
Principal Investigator
Palo Alto Veterans Institute for Research