Clinical profile of non alcoholic fatty liver disease and significance of hsCRP

Justification for study: Non alcoholic fatty liver disease is the most common cause of chronic liver disease worldwide. The global prevalence of Non alcoholic fatty liver disease is estimated to be as high as one billion. Liver biopsy being the gold standard, is too invasive, there’s a chance of sampling error and costly. There is a pressing need for more viable non invasive markers of severity. Timely intervention can revert the disease progression and play a significant role in bringing down the morbidity associated with the disease

Detailed description of procedure / processes: All patients admitted to Kasturba Hospital in the study period who are diagnosed as grade 2 and grade 3 fatty infiltration on USG abdomen, who meet the inclusion, exclusion criteria will be recruited for the study. Written and informant consent will be taken from the participants before initiating the study. Anthropometric data, investigative data including hsC-reactive protein levels and elastoscan reports are obtained from the proforma. Non alcoholic fatty liver fibrosis score and FIB4 score will be calculated using parameters obtained from the proforma. The above data will be compared and analyzed. Outcome measures include significance of hsCRP in NAFLD in predicting severity of NAFLD, study clinical profile of NAFLD, accuracy of non-invasive scoring systems of NAFLD