The Acute Effect of Interval-walking

Not Applicable

Completed

• Conditions: Type 2 Diabetes Mellitus
• Interventions: Behavioral: Continuous walking; Behavioral: Interval Walking

• Registration Number: NCT01987258
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

Four months of interval walking training (IWT) is superior to energy-expenditure matched continuous walking training (CWT) with regards to weight loss and improvements in glycemic control. The reason for this is unclear. One potential explanation for the differential outcome in weight loss is excess post-exercise oxygen consumption (EPOC), which is defined as the elevated oxygen consumption measured during the hours following an exercise bout. A large EPOC means greater energy expenditure which, if energy intake does not change, leads to a greater weight loss. This weight loss may subsequently improve glycemic control

* Aim 1: To assess the effect of an acute bout of IWT vs. an acute bout of CWT on glycemic control in type 2 diabetics and to assess mechanisms responsible for differences (if any). It is hypothesised that IWT will be more advantageous for improving glycemic control.

* Aim 2: To examine the effect of an acute bout of IWT vs. an acute bout of CWT on EPOC. It is hypothesised that IWT will produce an EPOC of larger magnitude than CWT.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-06
• Study First Submitted: 2013-06-28
• Study First Submitted QC: 2013-11-12
• Study First Posted: 2013-11-19
• Primary Completion: 2014-01
• Status Verified: 2014-02
• Study Completion: 2014-02
• Last Update Submitted: 2014-02-26
• Last Update Posted: 2014-02-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Diabetes mellitus, type 2

Exclusion Criteria

• Smoking
• Pregnancy
• insulin dependence
• Contraindication to physical activity (as judged by medical history and screening)
• Evidence of thyroid, liver, lung, kidney or heart disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Continuous walking	Continuous walking	A one hour continuous walking exercise bout
Interval Walking	Interval Walking	A one hour interval walking exercise bout

Primary Outcome Measures

Name	Time	Method
Glycemic control	Will be assessed immediately after the intervention using a mixed meal tolerance test (duration: 5 hours) followed by continuous glucose monitoring (duration: 48 hours).	Glycemic control will be assessed after a one hour specific exercise intervention (control/continuous walking/interval walking) in a controlled setting (a mixed meal tolerance test). Moreover, glycemic control will be assessed during the following 2 days in a free-living environment, using continuous glucose monitoring systems.

Secondary Outcome Measures

Name	Time	Method
Excess post-exercise oxygen consumption (EPOC)	Will be assessed immediately after the intervention using a ventilated hood (duration: 5 hours).	EPOC will be assessed during the hours following the before-mentioned specific exercise bouts using the indirect calorimetry ventilated hood technique.

Trial Locations

Locations (1)

Centre of Inflammation and Metabolism (CIM), Rigshospitalet, Tagensvej 20, section M7641; 🇩🇰 Copenhagen, Denmark