The Features Behind the Beneficial Effects of Interval-walking

Not Applicable

Completed

• Conditions: Diabetes Mellitus, Type 2
• Interventions: Behavioral: IW3; Behavioral: IW1; Behavioral: Control

• Registration Number: NCT02257190
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

A single bout of Interval-Walking (IW) exercise is superior to energy-expenditure and time-duration matched Continuous Walking (CW) exercise upon improving glycemic control. The reason IW is superior is unknown.

This study will look into whether it is the larger peak intensity during IW or if it is the alternating exercise pattern that is responsible for the larger improvements seen.

Subjects with type 2 diabetes will be included in a crossover, counter-balanced, controlled study, where each subject will undergo three trials. Trials will be identical except the following interventions:

1. One hour of rest (Con)

2. One hour of classical interval walking (repeated cycles of 3 min of fast and 3 min of slow walking; IW3)

3. One hour of fast alternating interval walking (repeated cycles of 1 min of fast and 1 min of slow walking; IW1).

After the interventions subjects will undergo a standardized mixed meal tolerance test, with consecutive measurements of blood glucose, insulin and c-peptide.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-10
• Study First Submitted: 2014-10-01
• Study First Submitted QC: 2014-10-01
• Study First Posted: 2014-10-06
• Primary Completion: 2015-05
• Status Verified: 2015-10
• Study Completion: 2015-10
• Last Update Submitted: 2015-10-28
• Last Update Posted: 2015-10-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Type 2 diabetes mellitus
• Body mass index > 18 but < 40 m2/kg
• Agreement to pause antidiabetic medication from 2 days before to after each trial

Exclusion Criteria

• Pregnancy
• Smoking
• Use of exogenous insulin
• Contraindication to increased levels of physical activity
• Evidence of thyroid, liver, lung, heart or kidney disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Interval Walking - 3 min intervals (IW3)	IW3	One hour of classical interval walking exercise (repeated cycles of 3 min of fast and 3 min of slow walking.
Interval Walking - 1 min intervals (IW1)	IW1	One hour of fast alternating interval walking exercise (repeated cycles of 3 min of fast and 3 min of slow walking
Control (Con)	Control	No exercise intervention.

Primary Outcome Measures

Name	Time	Method
Glycemic control	Within the first 4 hours after the interventions	Glycemic control will be measured after each intervention. Subjects will receive a standardized mixed meal tolerance test (MMTT), and blood glucose values will be obtained during the test.

Secondary Outcome Measures

Name	Time	Method
Insulin secretion	Within the first 4 hours after the interventions	Insulin and C-peptide will be measured during the MMTT
Insulin sensitivity	Within the first 4 hours after the interventions	From the measurements og glucose and insulin during the MMTT, various indices of insulin sensitivity will be assessed

Trial Locations

Locations (1)

Center for Physical Activity Research (CFAS); 🇩🇰 Copenhagen, Denmark