The Observation About the Effects of Internal Carotid Artery Stenosis on Fundus Vessels and the Changes of Fundus Vessels After Interventional Therapy

• Conditions: Internal Carotid Artery Stenosis

• Registration Number: NCT05260229
• Lead Sponsor: Qilu Hospital of Shandong University

Brief Summary

The investigators plan to collect 30 participants with internal carotid artery stenosis to observed the relationship between the degree of internal carotid artery stenosis and fundus vessels （and blood flow）density before operation, and compared with participants without internal carotid artery stenosis.The fundus blood flow density will be observed after intervention operation in order to see whether the operation is effective to improve the density of fundus vessels and blood flow or not.

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-10
• Study Start: 2021-12-12
• Study First Submitted: 2022-02-14
• Study First Submitted QC: 2022-02-24
• Last Update Submitted: 2022-02-24
• Study First Posted: 2022-03-02
• Last Update Posted: 2022-03-02
• Primary Completion: 2022-04-30
• Study Completion: 2022-05-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Patients who have been diagnosed with carotid artery stenosis and need surgery;
2. Patients whose vision won't get worse soon;
3. Patients have not had any eye surgeries;
4. Patients with complete profile.

Exclusion Criteria

1. Patients with severe systemic disease;
2. Patients with poor dioptric stroma;
3. Patients with nystagmus;
4. Patients with incomplete profile.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The perimeter and area of the fovea avascular zone（FAZ）in the Forum of the optical coherence tomography angiography（OCTA ）of Zeiss Company	2022-02-14	The differences between the perimeter and area of the fovea avascular zone（FAZ） of the carotid artery stenosis side before and after interventional surgery.
The differences of perfusion density in the Forum of the optical coherence tomography angiography（OCTA ）of Zeiss Company	2022-02-14	The perfusion density differences between the fundus vessels on the carotid artery stenosis side and the same side after interventional surgery.
The differences of vessel density in the Forum of the optical coherence tomography angiography（OCTA ）of Zeiss Company	2022-02-14	The vessel density differences between the fundus vessels on the carotid artery stenosis side and the same side after interventional surgery.

Trial Locations

Locations (1)

Department of ophthalmology and neurology at Qilu Hospital of Shandong University; 🇨🇳 Jinan, Shandong, China