Ultra Low Dose CT and Use of Iomeron 400 in PCD-CT

Not Applicable

Recruiting

• Conditions: Radiation Exposure; Lung Cancer; Lung Embolism; Pneumonia
• Interventions: Radiation: Computed Tomography

• Registration Number: NCT06360627
• Lead Sponsor: University of Zurich

Brief Summary

Evaluation of ultra low dose protocols and Iomeron 400 contrast in PCD-CT

Detailed Description

Not available

Study Timeline

• Study Start: 2023-02-20
• Study First Submitted: 2023-02-27
• Status Verified: 2024-04
• Study First Submitted QC: 2024-04-09
• Last Update Submitted: 2024-04-09
• Study First Posted: 2024-04-11
• Last Update Posted: 2024-04-11
• Primary Completion: 2027-03-31
• Study Completion: 2027-12-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• CT SCAN for pulmonary nodule detection/follow up
• CT SCAN for pneumonia detection/follow up

Exclusion Criteria

• under 18
• BMI over 30

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Low Dose	Computed Tomography	Standard Low Dose CT
Ultra Low Dose	Computed Tomography	Ultra Low Dose CT

Primary Outcome Measures

Name	Time	Method
stable Image Quality in reduced dose scans	through study completion, an average of 1 year	Recorded values compared in 2 populations-different contrast agents by using qualitative\&quantitative methods Qualitative:diagnostic certainty, assessability of lung structure/lesions,diagnostic reliability,; Quantitative:Assessment of tissue composition,diagnostic performance measurements Attenuation/sealing measurement (HU), signal-to-noise ratio (SNR), contrast-to-noise ratio ,size dimensions of lung structure/lesion in three dimensions in millimeters Tissue composition assessment diagnostic performance measurements (sensitivity, specificity, accuracy) diagnostic confidence: 1-4; Theses measurements will be put in correlation to the scan dose (mSv) per patient, forming two groups with matched BMI (kg/m\^2)
Dose Reduction by new scanner	through study completion, an average of 1 year	mSv per exam will be recorded. This value will be put in correlation to weight (Kg), height (cm) and BMI.

Trial Locations

Locations (1)

University Hospital Zurich - Diagnostic Radiology; 🇨🇭 Zurich, Switzerland