The Efficacy of Scaling and Root Planing on Endothelin-1 Gingival Crevicular Fluid Levels Among Periodontitis Patients: a Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 24
- 主要终点
- PPD
研究概览
简要总结
Periodontitis is a chronic inflammatory disease resulting from bacterial invasion. Endothelin (ET-1) is a potent vasoconstrictor critical in the pathophysiology of periodontal diseases.
Aim The present study aimed to measure the ET-1 concentrations in gingival crevicular fluid (GCF) at baseline, one and three months subsequently to non-surgical periodontal therapy.
Material and methods Designed as a clinical trial, 24 periodontitis individuals will be voluntarily consented to participate. Following non-surgical periodontal treatment, GCF samples will be collected to determine the amount of endothelin-1 at baseline, one, and three months. Clinical periodontal parameters will be recorded.
详细描述
Periodontitis is a chronic inflammatory disease resulting from bacterial invasion. Endothelin (ET-1) is a potent vasoconstrictor critical in the pathophysiology of periodontal diseases.
Aim The present study aimed to measure the ET-1 concentrations in gingival crevicular fluid (GCF) at baseline, one and three months subsequently to non-surgical periodontal therapy.
Material and methods Designed as a clinical trial, 24 periodontitis individuals will be voluntarily consented to participate. Following non-surgical periodontal treatment, GCF samples will be collected to determine the amount of endothelin-1 at baseline, one, and three months. Clinical periodontal parameters will be recorded.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •systemically healthy
- •Generalized unstable periodontitis with a moderately deep pocket (4,5 or 6 mm)
排除标准
- •subjects who wore dental prosthesis
- •teeth with grade II mobility,
- •alcoholic and smoker, had treated caries
- •underwent periodontal therapy within the last four months
研究组 & 干预措施
have generalized unstable periodontitis with a moderately deep pocket (4,5 or 6 mm).
got generalized unstable periodontitis with a moderately deep pocket (4,5 or 6 mm) will undergo scaling and root surface debritment
干预措施: Scaling and root surface debritment (Device)
结局指标
主要结局
PPD
时间窗: 3 months recall visits
changes in PPD after non-surgical periodontal treatment.
CAL
时间窗: 3 months recall visits
changes in CAL after non-surgical periodontal treatment.
次要结局
- ET-1(3 months recall visits)
研究者
Sarah Alrihaymee
Head of periodontic department
University of Baghdad