The effects of enteral Royal jelly supplementation in critically ill patients
- Conditions
- Supportive care critically ill patient stay in intentensive care unit.Symptoms and signs involving the digestive system and abdomen
- Registration Number
- IRCT2016073029127N1
- Lead Sponsor
- Vice chancellor for research, Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 30
Critically ill patients aged older than 18 years and less than 65 years; at least two signs of systemic inflammatory response syndrome (body temperature above 38 C° or less than 36 C°, heart rate more than 90 min without drug interactions , respiratory rate more than 20 in minutes, WBC lees than 4000 or more than12,000 or more than 10% immature neutrophils); at least a measure organ dysfunction syndrome (oliguria acute or urine output <0.5 ml/kg/min for at least two hours despite the revival of adequate fluids, coagulation disorders)
Exclusion criteria: Pregnancy and lactation; taking dose of antifungal ,catecholamine and vasopressor Drugs; Immunocompromised patients; liver failure (changes in liver enzymes more than twice normal); renal failure (serum creatinine levels> 2); gastric acidity(pH) less than 3.5
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Quantitative GUT microbiota pattern. Timepoint: Baseline,3 and 7 days after intervention. Method of measurement: Extraction and purification of DNA Microbiota of fecal samples or stomach juice by using Real-time PCR and Fast Start Univesal SYBR green master with Light cycler ® 96 and draw Amplification curve.;Serum Endocan Level. Timepoint: Baseline and seventh day after intervention. Method of measurement: Serum endocan levels is measured using an endocan enzyme-linked immunosorbent assay (ELISA) kit.
- Secondary Outcome Measures
Name Time Method Acute Physiologic Assessment and Chronic Health Evaluation (APACHE) II Scores. Timepoint: Baseline, 3 and 7 days after intervention. Method of measurement: Standard questionnaire.