Investigation of Respiratory Muscle Strength and Aerobic Capacity in Patients With Scleroderma
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Respiratory muscle strength assessment
研究概览
简要总结
Primary aim of this study was to compare respiratory muscle strength, aerobic capacity, dyspnea, pulmonary function tests and fatigue values with healthy controls. The secondary aim was to evaluate the relationship between respiratory muscle strength and other parameters in these patients and to examine the factors that may affect respiratory muscle strength. Respiratory muscle strength, aerobic capacity, respiratory function tests and fatigue will be evaluated
详细描述
Scleroderma is a systemic connective tissue disease characterized by progressive thickening of the skin, the etiology of which has not been fully elucidated, in which microvascular damage, immune activation and fibrosis play a role. Primary aim of this study was to compare respiratory muscle strength, aerobic capacity, dyspnea, pulmonary function tests and fatigue values with healthy controls. The secondary aim was to evaluate the relationship between respiratory muscle strength and other parameters in these patients and to examine the factors that may affect respiratory muscle strength. The study will include 15 patients and 15 healthy individuals of the same age and gender. Respiratory muscle strength, aerobic capacity, respiratory function tests and fatigue will be evaluated
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Being diagnosed with Ssk according to ACR/EULAR criteria
- •Stable medical treatment for 3 months
排除标准
- •Having a regular exercise habit (doing regular exercise at least once a week for the last 3 months)
- •Comorbidity with another chronic disease that may affect aerobic capacity or respiratory muscle strength
- •Having concomitant acute respiratory diseases
- •Having a smoking habit
- •History of orthopedic or neurologic disease in the lower extremities that may prevent cycling
结局指标
主要结局
Respiratory muscle strength assessment
时间窗: 5 minutes
Respiratory muscle strength will be assessed with an intraoral pressure gauge. These are the intraoral pressures measured at maximal respiration against a valve that closes the airways. When applying MIP, the patient is asked to perform maximal expiration. As a result, the patient is asked to maximally inspire against the closed airway and maintain this for 1-3 seconds. MEP, on the other hand, after maximal inspiration, the patient is asked to perform maximal expiration against the closed airway for 1-3 seconds.
次要结局
- Aerobic capacity assessment(10 minutes)
- Fatigue assessment(2 minutes)
- Pulmonary function test(5 minutes)
研究者
Songül Bağlan Yentür
Firat University
Firat University