Efficacy of Vaginal Progesterone for Maintenance Therapy in Arrested Preterm Labor: A Randomized Controlled Trial
- Conditions
- preterm labor at gestational age of 24 weeks to 33 weeks and 6 dayssuccessfully inhibited with Nifedipine as an acute phase tocolysis (arrested preterm labor)Preterm labor
- Registration Number
- TCTR20230901006
- Lead Sponsor
- Hatyai hospital
- Brief Summary
High-dose vaginal progesterone, as a maintenance agent, efficiently prolongs latency delivery day, reduces the rate of preterm birth and improves birth weight. However, it fails to delay the shortening of the cervix and does not decrease the rate of NICU admission.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 80
Pregnant women presented with preterm labor at gestational age of 24 completed weeks to 33 weeks and 6 days
lethal fetal anomaly
dead fetus in utero
non-reassuring fetal status
preeclampsia with severe features
unstable maternal vital signs
chorioamnionitis
patient allergic to progesterone or progestrogen
multifetal gestations
placenta previa
cervical os open more than 4 cm
history of cervical cerclage in this pregnancy
history of vaginal progesterone used in this pregnancy due to others indication for example ; short cervix
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method atency days from the day presented with preterm labor to the day of delivery Unpaired student T-test
- Secondary Outcome Measures
Name Time Method Gestational age at delivery Days,Birth asphyxia 1, 5 minutes after birth Apgar score,NICU admission after delivery Yes or no,Low birthweight at delivery Grams