The role of the dopamine D2 receptor system in pornographic addiction - A [11C]-Raclopride PET study

Completed

• Conditions: gedragsverslavingen; compulsive pornography use; excessive pornography use

• Registration Number: NL-OMON40724
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 28

Inclusion Criteria

Subjects with pornographic addiction
- male sex
- age between 18 and 45
- a modified CIUS score>3;Control subjects:
- male sex
- age between 18 and 45
- a modified CIUS score of 1

Exclusion Criteria

- lifetime DSM-IV axis I disorder,
- drug dependence or abuse; including alcohol (i.e. drinking more than 30 drinks per month or any illicit drug use during the past 30 days);
- active medical condition;
- treatment in the last 6 months with antidepressants, neuroleptics, sedative hypnotics, glucocorticoids, appetite suppressants, sex hormone, opiate or dopamine medications
- use of psychoactive medications within the past 30 days;
- lifetime history of seizure disorder or closed head trauma;
- participation in a scientific research study (<1 year) involving radiation
- Contra-indications for MRI-scanning

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are the [11C]-raclopride binding potential in the<br /><br>striatum in subjects with pornographic addiction and control subjects. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary study parameters are cerebral blood flow measurements using<br /><br>ASL-MRI, the scores on the modifed Compulsive Internet Use Scale, and<br /><br>questionairres assessing impulsiveness and sensation seeking.</p><br>