The dopaminergic system in pornography addiction.

• Conditions: pornographic addiction; Therapeutic area: Body processes [G] - Physiological processes [G07]

• Registration Number: EUCTR2014-001284-12-NL
• Lead Sponsor: niversity Medical Center Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-06-04
• Last Update Posted: 1 December 2014

Recruitment & Eligibility

• Status: Authorised-recruitment may be ongoing or finished
• Sex: Male
• Target Recruitment: Not specified

Inclusion Criteria

- male sex
- age between 18 and 45
- a modified CIUS score>3
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 28
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

- lifetime DSM-IV axis I disorder,
- drug dependence or abuse; including alcohol (i.e. drinking more than 30 drinks per month or any illicit drug use during the past 30 days);
- active medical condition;
- treatment in the last 6 months with antidepressants, neuroleptics, sedative hypnotics, glucocorticoids, appetite suppressants, sex hormone, opiate or dopamine medications
- use of psychoactive medications within the past 30 days;
- lifetime history of seizure disorder or closed head trauma;
- participation in a scientific research study (<1 year) involving radiation
- Contra-indications for MRI-scanning

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main Objective: The primary objective is to determine the dopamine D2 receptor availability and dopaminergic function in subjects with pornographic addiction and to compare the availability with control subjects.;Secondary Objective: The secondary objectives are to correlate the dopamine D2 receptor availability to prefrontal cerebral blood flow, the severity of addiction as measured by the Compulsive Internet Use Scale (CIUS), and personality traits of impulsivity and sensation seeking.;Primary end point(s): n/a;Timepoint(s) of evaluation of this end point: n/a

Secondary Outcome Measures

Name	Time	Method
Secondary end point(s): n/a;Timepoint(s) of evaluation of this end point: n/a