Differences between dopa-responsive and dopa-resistant Parkinson's tremor

Recruiting

• Conditions: Parkinson's disease; tremor; fMRI; GABA

• Registration Number: NL-OMON20997
• Lead Sponsor: Radboud University NijmegenDonders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

PHASE 1 (polymography):

- Idiopathic Parkinson's disease according to UK brain bank criteria.

Exclusion Criteria

- Neurological or psychiatric co-morbidity (e.g. stroke, depression).

- Severe head tremor or dyskinesias.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
- fMRI activity (cerebral activity related to the onset and the amplitude of each patient’s tremor episodes).<br /><br>- GABA concentration in the ventrolateral thalamus contralateral to the tremulous arm.<br /><br>- structural integrity of the mesencephalon contralateral to the tremulous arm.

Secondary Outcome Measures

Name	Time	Method
- Cognitive performance on dopamine-dependent and dopamine-independent<br>behavioural tasks.<br /><br>- Electrophysiological markers of dopa-responsive and dopa-resistant tremor (EMG).