Dopaminergic neurotransmission and cognitive deterioration in velocardiofacial syndrome
Completed
- Conditions
- deletion 22q11.2DiGeorge syndrome10083624
- Registration Number
- NL-OMON33641
- Lead Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 44
Inclusion Criteria
Deletion 22q11.2
Group 1: premorbid IQ > 70 . At this moment IQ < 55
Group 2: premorbid IQ < 55
Exclusion Criteria
Pregnancy
Age < 18 and > 65
Somatic problems which mimic dementia, such as hypothroid.
Psychiatric disorders with dementia like symptoms, such as depressive disorder and dementia's of other origine
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Blood and urine samples will be collected to determine dopaminergic markers.<br /><br>Also we will obtain blood samples to determine erythrocyte COMT activity,<br /><br>proline levels in serum and COMT and PRODH polymorphisms. Behavioural and<br /><br>psychiatric parameters will be obtained through several questionnaires. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Medication status wil be added.</p><br>