Dopaminergic modulation of cognition and psychomotor functio

Recruiting

Conditions: geen aandoening
not applicable

Registration Number: NL-OMON38372

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

• Male or female
• 18 to 45 years of age
• Healthy (i.e. absence of all exclusion criteria), normal static binocular acuity (corrected or uncorrected),
• Body mass index between 18.5 and 30
• Willingness to sign an informed consent.

Exclusion Criteria

- history of cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal, haematological or psychiatric illness.
- having suffered from depression, bipolar disorder, anxiety disorder, panic disorder, psychosis, or attention deficit hyperactivity disorder
- those volunteers who have a first-degree relative with a psychiatric disorder or a history with a psychiatric disorder
- excessive drinking (>20 glasses of alcohol containing beverages a week), pregnancy or lactation, use of medication other than oral contraceptives, use of recreational drugs from 2 weeks before until the end of the experiment, and any sensory or motor deficits which could reasonably be expected to affect test performance.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main endpoints are the Contingent Negative Variation (CNV) amplitude in the<br /><br>electroencephalogram (EEG) and the response time on the Response preparation<br /><br>(Lines and Stoplight) tasks. For memory functions: total number of words<br /><br>recalled at immediate recall in word learning test (WLT); number of words<br /><br>recalled in WLT at delay of 30 min and 24h; accuracy and reaction time<br /><br>recognition test of WLT, heart rate, prolactine levels in blood. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary parameters are performance on a Sternberg memory scanning task,<br /><br>Object relocation, Set shifting, paired associates learning test; Visual<br /><br>analogue scales: Profile of moods states (POMS) and Bond & Lader (B&L); Resting<br /><br>EEG.</p><br>