Is Adipose Tissue a Reservoir for SARS-Cov2 Spread in Covid-19 Patients?
Not Applicable
Completed
- Conditions
- Covid-19 Patients
- Interventions
- Procedure: biopsies of subcutaneous adipose tissue
- Registration Number
- NCT04427878
- Lead Sponsor
- Centre Hospitalier Universitaire de Nice
- Brief Summary
Resident cells of human adipose tissue express ACE2 and DPP4, receptors for SARS-Cov2. The hypothesis is that the virus may enter and spread in fat depots.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 5
Inclusion Criteria
- Male or female ≥ 18 years old
- Patients testing positive for Covid19
- Patients affiliated to social security
- Signing of free and informed consent
Exclusion Criteria
- Vulnerable persons (- minors,
- adults under guardianship or curatorship,
- pregnant women,
- persons deprived of their liberty,
- persons who do not master the French language)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description patients with Covid-19 biopsies of subcutaneous adipose tissue -
- Primary Outcome Measures
Name Time Method The presence of SARS-CoV2 in adipose tissue of Covid19 patients Day 0 RT-qPCR for SARS-Cov-2 from RNAs and by immunodetection
- Secondary Outcome Measures
Name Time Method The expression of inflammatory cytokines in adipose tissue of Covid19 patients Day 0 RT-qPCR for TNFa
Trial Locations
- Locations (1)
CHU de Nice
🇫🇷Nice, France