Study of IGRP-specific T Cell in Peripheral Blood of Type 1 Diabetes Mellitus

Completed

• Conditions: Diabetes Mellitus
• Interventions: Other: No intervention

• Registration Number: NCT03136939
• Lead Sponsor: First Affiliated Hospital of Zhejiang University

Brief Summary

10 type 1 diabetes, 10 type 2 diabetes and 10 healthy controls matched with age and sex were enrolled in our study and their periphera blood mononuclear cells (PBMC) were isolated. We implemented ELISPOT(Enzyme-linked Immunospot Assay) to detect the interferon-γ (IFN-γ）which secreted by IGRP-specific T cell. Results were compared between these groups.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-01-01
• Status Verified: 2017-04
• Study First Submitted: 2017-04-28
• Study First Submitted QC: 2017-04-28
• Study First Posted: 2017-05-02
• Primary Completion: 2017-05-30
• Study Completion: 2017-05-31
• Last Update Submitted: 2017-06-28
• Last Update Posted: 2017-07-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• the criteria of type 1 and type 2 diabetes

Exclusion Criteria

• no diabetes

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
type 1 diabetes	No intervention	-
type 2 diabetes	No intervention	-
healthy people	No intervention	-

Primary Outcome Measures

Name	Time	Method
the rate of positive reactivation against the IGRP epitopes	5 months

Trial Locations

Locations (1)

Department of Endocrinology, the First Affiliated Hospital to Zhejiang University School of Medicine; 🇨🇳 Hangzhou, Zhejiang, China