New Echocardiographic Parameters for Assessment of Longitudinal Left Ventricular Function
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Cardiovascular Pathology
- Sponsor
- Heidelberg University
- Enrollment
- 400
- Locations
- 1
- Primary Endpoint
- left ventricular longitudinal systolic strain (LV-LSS) in all patients
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Assessment of left ventricular systolic function is the most frequent indication for routine echocardiography. Qualitative eyeball method and biplane modified Simpson's rule, both measuring radial ventricular function, are the currently recommended methods to meet this challenge. Due to the complexity of the myocardial architecture, global left ventricular function also has longitudinal and torsional components.
The aim of this study is to evaluate new echocardiographic parameters for longitudinal left ventricular function. A special focus is set on strain imaging by speckle tracking, which is a relatively new technique. Patients with different cardiac pathologies (e. g. dilated cardiomyopathy, coronary artery disease, diastolic dysfunction) will be included and compared to healthy individuals.
Investigators
Derliz Mereles
Dr. Derliz Mereles
Heidelberg University
Eligibility Criteria
Inclusion Criteria
- •persons of 18 years and older who receive a transthoracic echocardiography at our department
- •written consent
Exclusion Criteria
- •permanent pacemaker rhythm
- •moderate/severe valvular heart disease
Outcomes
Primary Outcomes
left ventricular longitudinal systolic strain (LV-LSS) in all patients
Time Frame: 2 years
left ventricular longitudinal systolic strain (LV-LSS) is measured in all patients by speckle tracking strain imaging
Secondary Outcomes
- mitral annular plane systolic excursion (MAPSE) in all patients(2 years)
- mitral annular systolic velocity (MASV) in all patients(2 years)
- diastolic left ventricular function in all patients(2 years)
- left ventricular ejection fraction (LVEF) in all patients(2 years)
- pulmonary artery systolic pressure (PASP) in all patients(2 years)