New Echocardiographic Parameters for Assessment of Longitudinal Left Ventricular Function

Completed

• Conditions: Cardiovascular Pathology

• Registration Number: NCT01275963
• Lead Sponsor: Heidelberg University

Brief Summary

Assessment of left ventricular systolic function is the most frequent indication for routine echocardiography. Qualitative eyeball method and biplane modified Simpson's rule, both measuring radial ventricular function, are the currently recommended methods to meet this challenge. Due to the complexity of the myocardial architecture, global left ventricular function also has longitudinal and torsional components.

The aim of this study is to evaluate new echocardiographic parameters for longitudinal left ventricular function. A special focus is set on strain imaging by speckle tracking, which is a relatively new technique. Patients with different cardiac pathologies (e. g. dilated cardiomyopathy, coronary artery disease, diastolic dysfunction) will be included and compared to healthy individuals.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01
• Study First Submitted: 2011-01-12
• Study First Submitted QC: 2011-01-12
• Study First Posted: 2011-01-13
• Primary Completion: 2016-10
• Study Completion: 2016-10
• Status Verified: 2016-11
• Last Update Submitted: 2016-11-05
• Last Update Posted: 2016-11-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

• persons of 18 years and older who receive a transthoracic echocardiography at our department
• written consent

Exclusion Criteria

• permanent pacemaker rhythm
• moderate/severe valvular heart disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
left ventricular longitudinal systolic strain (LV-LSS) in all patients	2 years	left ventricular longitudinal systolic strain (LV-LSS) is measured in all patients by speckle tracking strain imaging

Secondary Outcome Measures

Name	Time	Method
mitral annular plane systolic excursion (MAPSE) in all patients	2 years	MAPSE is measured by M-Mode echocardiography
mitral annular systolic velocity (MASV) in all patients	2 years	MASV is derived from tissue doppler
diastolic left ventricular function in all patients	2 years	Diastolic function is assesed by mitral inflow, mitral annulus velocity, pulmonary vein flow and velocity of flow progression.
left ventricular ejection fraction (LVEF) in all patients	2 years	EF is measured by modified Simpson's rule (biplane)
pulmonary artery systolic pressure (PASP) in all patients	2 years	PASP is derived from Tricuspid valve regurgitation velocity

Trial Locations

Locations (1)

University of Heidelberg; 🇩🇪 Heidelberg, Germany