The Effect of Assisted Hatching on Implantation Rate in Frozen Blastocyst Transfer - a Prospective Randomized Controlled Study
试验速览
- 阶段
- 不适用
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- Implantation rate
研究概览
简要总结
The current study aims to assess the effect of assisted hatching on the implantation rate of frozen blastocytes.
详细描述
The Zona Pellucida protects the ovum from the penetration of multiple sperm, and from mechanical and physiological damage until the fertilized ovum reaches the uterus. Subsequently, spontaneous hatching occurs, and enables the embryo to attach to the endometrium. The technique of assisted hatching was originally investigated as a means to improve implantation in cases of zona hardening, and is commonly performed in 3-day embryos. In the current study, the investigators aim to investigate the effect of assisted hatching on 5-day frozen embryos.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 39 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •In-vitro fertilization patients at the investigators' institution, intended to undergo a transfer of a frozen five-day embryo (blastocyte)
- •18 to 39 years old
- •First to third treatment cycle
- •Patient has previously had a maximum of four embryos transferred.
排除标准
- •Over 40 years old
- •Congenital or acquired uterine malformations
- •Hydrosalpinx
- •Chronic autoimmune diseases
- •Embryo intended to be undergo preimplantation genetic diagnosis
研究组 & 干预措施
Assisted hatching
Five-day frozen embryos will undergo assisted hatching prior to embryo transfer
干预措施: Assisted hatching (Procedure)
Control
Five-day frozen embryos will not undergo any additional procedures prior to embryo transfer
结局指标
主要结局
Implantation rate
时间窗: Five to six weeks following embryo transfer
Number of gestational sacs demonstrated on ultrasound divided by the number of embryos transferred (expressed as percentage)
次要结局
- Early spontaneous abortion(Up to 15 weeks from embryo transfer)
- Chemical pregnancy(Five to six weeks following embryo transfer)
研究者
Hadas Ganer Herman
Principal Investigator
Wolfson Medical Center