Synchronizing Blastocyst at Hatching Stage in Frozen Embryo Transfer Cycles

Al-Yasmeen Fertility and Gynecology Center2 sites in 1 country742 target enrollmentApril 21, 2017

ConditionsEmbryo Implantation

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Embryo Implantation
Sponsor: Al-Yasmeen Fertility and Gynecology Center
Enrollment: 742
Locations: 2
Primary Endpoint: Ongoing implantation rate
Status: Completed
Last Updated: 6 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The aim of the present study is to determine if implantation rate could be increased in women undergoing frozen embryo transfer cycles in case of adjusting their embryo development at hatching stage.

Registry

clinicaltrials.gov

Start Date

April 21, 2017

End Date

May 10, 2018

Last Updated

6 years ago

Study Type

Interventional

Study Design

Parallel

Sex

Female

Investigators

Sponsor

Al-Yasmeen Fertility and Gynecology Center

Responsible Party

Principal Investigator

Yasmin Magdi

Al-Yasmeen Fertility and Gynecology Center

Eligibility Criteria

Inclusion Criteria

•Patients who will agree to participate and assign an informed consent form
•Only blastocyst transfer FET cycles
•Patients undergoing FET after their 1st IVF or ICSI cycle with no pregnancy at the fresh transfer
•Freeze-all cycles due to OHSS
•Freeze-all cycles due to poor endometrium
•Age 19-33 at the time of randomization.
•Their frozen blastocysts are 3 or less grade of expansion.
•Female with a ≥12 AFCs
•Endometrial thickness ≥ 8mm at the time of ovulation
•Women with their male partners will give only fresh semen

Exclusion Criteria

•Cycles undergoing preimplantation genetic diagnosis.
•Women who have previous two cycles of implantation failure at fresh transfer
•Women who have previous two FET failed cycles
•Any uterine pathology (myomas, adenomyosis, endocrinopathies, thrombophilia, chronic pathologies, acquired or congenital uterine abnormalities)
•Patients with severe endometriosis
•Presence of uni- or bilateral hydrosalpinx
•Recurrent pregnancy loss.
•Any medical condition that affect fertility.