The Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by Impedance Cardiography in Early Pregnancy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Cardiac output
研究概览
简要总结
The purpose of the research is to characterize the effect of labetalol, atenolol, and nifedipine on maternal hemodynamics early in pregnancy. Patients will be given medication based on their hemodynamics and asked to return for a repeat measurement.
详细描述
When a patient presents to the Maternal Hypertension Center at Cabell Huntington Hospital, she will receive a non-invasive hemodynamic assessment via the NICaS system as per usual protocol. The NICaS system uses impedance cardiography which provides a reliable assessment of cardiovascular, respiratory, and fluid parameters. In typical practice, the vasodilator nifedipine is initiated for increased systemic vascular resistance and elevated cardiac output is treated with beta blockade (via either atenolol or labetalol). The medication to be given to each subject will be based on their hemodynamics. Specifically, nifedipine will be given for a mean arterial pressure >100 and a beta blocker will be given for a cardiac output >8 l/min. The patients will be asked to return in one week for repeat ICG measurement.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Patients presenting to Maternal Hypertension Center at Cabell Huntington Hospital
- •English speaking
- •18-45 years old.
- •Willing to provide informed consent
- •Gestational age prior to 15 weeks gestation
排除标准
- •Non-English speaking patients, patients
- •<18 years old or >45 years old
- •Not willing or able to provide consent
- •Gestational age >15 weeks
研究组 & 干预措施
Beta blockade
Beta blocker (labetalol or atenolol) will be given for a cardiac output >8 l/min.
干预措施: Labetalol (Drug)
Beta blockade
Beta blocker (labetalol or atenolol) will be given for a cardiac output >8 l/min.
干预措施: Atenolol (Drug)
Nifedipine
Nifedipine will be given for a mean arterial pressure >100.
干预措施: Nifedipine (Drug)
结局指标
主要结局
Cardiac output
时间窗: Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.
Measured in liters per minute
Systemic vascular resistance
时间窗: Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.
Measured by dynes · sec/cm\^-5
Heart rate
时间窗: Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.
Measured in beats per minute
Systolic blood pressure
时间窗: Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.
Measured in mmHg
Diastolic blood pressure
时间窗: Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.
Measured in mmHg
Mean arterial pressure
时间窗: Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later.
Measured in mmHg
次要结局
未报告次要终点
研究者
Jesse Cottrell
Assistant Professor
Marshall University