Predictors of Cord Blood Immunoglobin E (IgE) Levels
试验速览
- 阶段
- 不适用
- 入组人数
- 800
- 试验地点
- 1
- 主要终点
- cord blood IgE
研究概览
简要总结
Background: Increased total serum IgE levels are a common characteristic of atopic diseases. Increased cord blood IgE levels, in conjunction with a family history of atopy, are associated with the development of allergic diseases in children. However, little is known about predictors of cord blood IgE levels.
Objective: The aim of our study was to identify predictors of cord blood IgE levels in an ongoing large birth cohort of infants with or without a family history of atopy.
Methods: Blood sampling of mothers was performed just before the delivery of newborns. Cord blood was also collected when the child was born. Maternal and cord blood was measured for IgE levels and cytokines. Questionnaires were administered after birth of the infant.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Mothers in pregnancy 18 years of age or older, AND
- •Mothers able to speak Chinese.
排除标准
- •Infant delivered at less than 36 weeks' gestation,
- •Infant with Apgar score in 5 minutes after birth < 7,
- •Infant with a major congenital anomaly, OR
- •Infant admitted to an intensive care unit.
结局指标
主要结局
cord blood IgE
时间窗: at birth
次要结局
- Cord blood cytokines or other mediators(at birth)