Eosinophil Markers and Development of Disease in Allergic Rhinitis

Completed

• Conditions: Seasonal Allergic Rhinitis

• Registration Number: NCT01192386
• Lead Sponsor: University of Aarhus

Brief Summary

Inflammatory proteins from eosinophil granulocytes in blood from patients with seasonal allergic hayfever have been shown to predict development of asthma at a six-year follow-up. This study is a 15-year follow-up of the same patients to verify earlier results and study disease development.

Detailed Description

The study consists of a single visit at which patients fill in a questionnaire on actual hayfever and asthma symptoms as well as current treatment. Blood samples and nasal lavages are drawn and analysed for eosinophils as well as eosinophil cationic protein and tryptase. Spirometry is performed.

If patients use drugs which can interfere with results, ie. corticosteroids or beta-agonists, biochemistry and/or spirometry are omitted.

Study Timeline

• Study Start: 2010-05
• Primary Completion: 2010-05
• Study Completion: 2010-05
• Status Verified: 2010-08
• Study First Submitted: 2010-08-30
• Study First Submitted QC: 2010-08-31
• Last Update Submitted: 2010-08-31
• Study First Posted: 2010-09-01
• Last Update Posted: 2010-09-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 29

Inclusion Criteria

• Participant in earlier study (1995)

Exclusion Criteria

• Treatment with any kind of corticosteroid within two months will exclude from study of inflammatory parameters

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Asthma morbidity	Single measurement - May 2010	Patients are asked whether they have experienced asthmatic symptoms or have been disgnosed with asthma within the latest 15 years

Secondary Outcome Measures

Name	Time	Method
Rhinitis morbidity	Single measurement - May 2010	Patients are asked for current hayfever symptoms